Faculty

a b c d e f g h i j k l m n o p q r s t u v w x y z All
(Includes Name, Title, Research Interests)
Biomedical Engineering
Research Interests:

The long-term goals of the Nano-Omic-Bio-Engineering-Lab (NOBEL) are to understand and engineer muscle function. Muscle is the primary organ system that defines our complex movements and to a degree our life and joy (“joy’s soul lies in the doing” – W. Shakespeare). Of the 3 muscle types (skeletal, cardiac, smooth), we mostly focus on skeletal muscle, which is composed of a constellation of cell types, consumes significant amounts of metabolic energy, grows and adapts its structure and function based on its environment and uniquely repairs and regenerates when damaged. Generating...

Cell and Developmental Biology
Research Interests:

Research in the Allen Lab is broadly focused on understanding the mechanisms of growth factor and morphogen signaling in development and disease. Specifically, we study the regulation of Hedgehog signaling during embryonic and postnatal development, as well as adult tissue homeostasis, repair and regeneration. Our research employs a wide range of approaches, including mouse genetics, chicken in ovo electroporations, biochemistry, and cell biology. The long-term goal of this work is to apply insights gained from the study of HH signaling in normal contexts to the treatment of a broad...

Pharmacology
Research Interests:

Our lab uses optical and electrophysiological techniques to study how hormone trafficking, signaling, and release are regulated in neurosecretory cells. We investigate these processes as they relate to stress and stress transduction at the sympatho-adrenal synapse.

Human Genetics, Neurology
Research Interests:

Our objective is to obtain a better understanding of the development and function of neurons and glia in the peripheral nervous system using human genetics, molecular and cellular biology, and zebrafish transgenesis. The major end goal of these studies is to characterize how these cell types are affected in patients with peripheral neuropathies.

Ophthalmology and Visual Sciences
Research Interests:

Our laboratory is interested in understanding the cellular and molecular basis of the blood-brain and blood-retinal barrier and how these barriers are compromised in diseases such as diabetic retinopathy or brain tumors. The long-term goal of this research is to develop novel therapies to restore normal barrier function.

Dr. Peter Arvan
Internal Medicine
Research Interests:

Our lab uses cellular and mouse models to study protein folding and misfolding in pancreatic beta cells (proinsulin) and thyroid epithelial cells (thyroglobulin), in order to discover new treatments for conformational diseases that affect these cells of the endocrine system. Our lab has described the cellular and molecular basis for the human disease known as Mutant INS gene-induced Diabetes of Youth, caused in most cases by expression of misfolded mutant proinsulin.  

Molecular, Cellular, and Developmental Biology
Research Interests:

The effects of sensory experience and sleep on neural circuits, mechanisms underlying nervous system plasticity and memory formation.

Cell and Developmental Biology, Biomedical Engineering, PIBS
Research Interests:

Molecular and cellular studies of auditory system development and regeneration in the mouse (including transgenic approaches), chick, zebrafish and immortalized inner ear cell lines. Studies of hormonal regulation of the tumor suppressor gene, neurofibromatosis I, using embryonic mouse stem cell approaches. Microfluidic organ cultures of inner ears and zebrafish for studies of morphogenesis.

Molecular and Cellular Developmental Biology
Research Interests:
Protein folding, disulfide bond formation.

 

Neurology
Research Interests:

We are interested in the basic abnormalities leading to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Using a combination of automated fluorescence microscopy, computer science, genome engineering and optogenetics we investigate RNA and protein metabolism, how deficiencies in these pathways lead to neuron loss in ALS and FTD, and how these pathways can be modified to prevent neurodegeneration.

Cell and Developmental Biology
Research Interests:

My lab studies the mechanisms by which transcriptional enhancers control gene expression during development, using genetic, biochemical, evolutionary, and bioinformatics approaches. We focus on enhancers that are directly regulated by cell signaling pathways, including Hedgehog, Wnt, Notch, and MAPK, all of which play important roles in development and disease.

Molecular & Integrative Physiology
Research Interests:
Research in Dr. Beard's laboratory is focused on systems engineering approaches to understanding the operation of physiological systems in health and disease. Projects include theoretical and experimental analysis of metabolic systems, whole-body cardiovascular mechanics and transport, blood-flow regulation, mechanisms of renal solute transport.

 

Human Genetics
Research Interests:

Discovery of new genes for human developmental brain disorders highlights the genes essential for brain development. The disease mechanisms associated with these genes are modeled using patient induced pluripotent stem cells and mice to understand the associated molecular pathology.

Internal Medicine
Research Interests:
Our laboratory studies the role of small RNAs including microRNAs in modulating signaling cascades that mediate renal injury and aging.

 

Computational Medicine and Bioinformatics, Human Genetics, Medical School
Research Interests:

Our research group aims to combine both computational and wet lab strategies to answer questions related to the transcriptional regulatory control of human genes. We believe that a complex regulatory control determines the fates of individual non-coding regulatory elements and that the integration of diverse genetic, epigenetic, and disease data is the best way to explore this control. Using innovative computational and wet lab approaches the lab both characterizes the function of these regulatory elements as well as examines the effect of genetic variation in these regions.

Cell and Systems Biology, Genomics/Proteomics, Computational Biology, Cancer Biology
Research Interests:
The overarching goal of the lab is to identify putative predictive genomic biomarkers for targeted therapies and understand primary and secondary resistance mechanisms for these therapies. The lab utilizes next generation sequencing strategies for the development and analysis of genomics-driven medicine clinical trials (precision medicine) and genetic characterization of therapeutic resistance. The lab also specializes in using high-throughput functional screens to identify therapeutic targets and molecular strategies to advance for pre-clinical modeling in cell lines and patient-derived...
Internal Medicine, Obstetrics and Gynecology
Research Interests:

Our lab is interested in the study of the tumor vascular niche; this includes tumor vascular cells, tumor stem cells and mesenchymal stem cells. We are studying both the basic biology and developing therapeutics to disrupt the vascular niche and thereby inhibit the growth of tumor stem cells.

Internal Medicine, Mol. Integ. Physiol.
Research Interests:

Our laboratory is interested in understanding how cells use nutrients and how excess nutrient flux, as occurs in obesity, and diabetes, triggers insulin resistance and inflammatory responses. We are also interested in how intrinsic exercise capacity and exercise training can alter metabolism. We use metabolomics profiling and other 'omics technologies to profile metabolism in animals and humans.

Human Genetics, Psychiatry
Research Interests:

We use genomic approaches to find and characterize genes involved in behavioral, neurological and psychiatric diseases, especially ataxia, depression and drug abuse. We follow their effects in culture on neurons differentiated from induced pluripotent stem cells from patients, and in animal models.

Molecular and Cellular Developmental Biology
Research Interests:

The Cadigan lab is interested in signal transduction and gene regulation in Drosophila and mammalian cells. Much of our research is focused on the Wnt/beta-catenin signaling pathway, but we are also exploring other pathways involved in cell specification during development and human disease.

Human Genetics
Research Interests:

Birth defects research, organogenesis, mouse models of human disease growth insufficiency including hormonal and skeletal dysplasia, hearing and vestibular dysfunction.

Pharmacology
Research Interests:

We study pathways involved in preserving genome stability as well as mechanisms of resistance to cancer chemotherapy.  

Otolaryngology/Head and Neck Surgery; Periodontics and Oral Medicine; Pharmacology
Research Interests:
We are studying the role of high risk human papillomaviruses (HPV) in head and neck squamous cell carcinoma (HNSCC). Specifically, we are focusing on the mechanisms that determine which HPV-positive tumors are likely to have excellent responses to treatment and those that require more aggressive treatment. We are examining site of integration, effects of integration site on gene function, and other genetic aberrations that determine tumor cell behavior.

 

Microbiology and Immunology
Research Interests:

Our research team is identifying how the promiscuous intracellular parasite Toxoplasma gondii uses autophagy to persist indefinitely in its hosts and employs cytolytic proteins to escape from infected cells. We are also developing new tools to disrupt processes required for persistence and pathogenesis to ameliorate disease.

Mol. Integ. Physiol
Research Interests:

Signal transduction pathways used by cytokine receptors and JAK tyrosine kinases; molecular actions of growth hormone; role of SH2-B adapter proteins in regulation of the cytoskeleton, gene expression and cellular differentiation and survival.

Microbiology and Immunology
Research Interests:
The impact of Immune receptor diversity in the response to mutable pathogens and tumors; Immunological memory and transplantation; Mutable vaccines.

 

Molecular and Cellular Developmental Biology
Research Interests:

We are working on protein sorting and quality control in the yeast secretory pathway.

Internal Medicine
Research Interests:

The Role of Nuclear Receptors in Obesity/Diabetes-Related Cardiovascular Complications.

Internal Medicine - Hematology/Oncology
Research Interests:

We study the communications between transcription factors that result in epigenetic modifications at super-enhancers of oncogenes. These changes drive the development of normal lymphocytes , but also the generation of cancer stem cells in childhood leukemia. By targeting specific, synthetic lethal interactions responsible for the context dependence of transcription factors in cancer, we might combat the cancer functions of transcription factors without potential adverse consequences of total inhibition.

Michigan Center for Translational Pathology
Research Interests:

Dr. Chinnaiyan's laboratory has focused on functional genomic,proteomic and bioinformatics approaches to study cancer for the purposesof understanding cancer biology as well as to discover clinicalbiomarkers. He and his collaborators have characterized a number ofbiomarkers of prostate cancer including AMACR, EZH2 and hepsin. AMACRis being used clinically across the country in the assessment of cancerin prostate needle biopsies.

Biological Chemistry
Research Interests:

My lab is mainly focusing on biochemical and structural studies on kinetochore assembly, histone chaperones, and Sestrin-mediated mTORC1 regulation.

Microbiology and Immunology
Research Interests:

We are broadly interested in the cell biology of T lymphocyte (T cell) function. These immune cells are central to cell-mediated immunity to infections and cancers. My laboratory uses high-resolution imaging approaches (including TIRFM, 3D super-resolution fluorescence microscopy, and transmission electron microscopy) to understand the molecular and subcellular mechanism by which T cells recognize and respond to pathogenic threats.

Internal Medicine
Research Interests:

Our lab is interested in the proteolytic ECM remodeling of adipose tissues in development and obesity. Using 3-D adipocyte differentiation model and a series of genetically modified mice, we aim to define a molecular mechanism that links ECM remodeling to the regulation of organ function in development and diseases.

Molecular, Cellular, and Developmental Biology
Research Interests:

Biology contravenes entropy, yet many biological mechanisms are sensitive to noise and thus take advantage of entropy as a generative force. Stochastic mechanisms contribute to the production of antibodies, olfactory receptor choice, and neuronal self-avoidance. The Clowney lab is interested in how non-deterministic mechanisms requiring relatively little genetic information can produce diverse molecular affinities and cellular behaviors across cells of a single ontogenetic type.

Internal Medicine/Micro and Imm
Research Interests:
Molecular Mechanisms of HIV Disease Pathogenesis.

 

Cell & Developmental Biology
Research Interests:

Our laboratory studies differentiation and homeostasis in complex epithelia, in health and in disease (e.g., monogenic disorders, cancer). We study these processes from the unique perspective of the keratin intermediate filament multigene family, and focus on skin epithelia. Our research activities range from the creation and validation of transgenic mouse models in vivo to biochemical and biophysical studies on purified proteins in vitro.

Dr. William Dauer
Neurology
Research Interests:

We are focused on unraveling the pathogenesis of Parkinson's disease and dystonia. Our studies are focused on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.

Urology
Research Interests:
Proteolytic processing of tumor cells in prostate cancer metastasis. Regulation of novel E2F1 target genes following disruption of the Rb/E2F pathway in human cancer.

 

Cell and Systems Biology, Cell Physiology, Biochemistry, Genetics/Gene Regulation, Molecular Mechanisms of Disease
Research Interests:

My laboratory studies disease mechanisms in cardiomyopathies with a major area of focus on regulation of the ubiquitin proteasome system in protein turnover and degradation. We are exploring the interaction between inflammation, proteasome dysfunction and ventricular remodeling in the heart. We are also interested in disease pathways triggered by sarcomere mutations in hypertrophic cardiomyopathy and understanding the interactions of the mutant allele product with RNA and protein surveillance systems.

Dermatology
Research Interests:

Embryonic signaling pathways in development, regeneration, and neoplasia.

Pathology
Research Interests:

The Dressler lab utilizes genetic and biochemical approaches to understand the development of the kidney and reproductive tract. The lab has identified multiple epigenetic and cell signaling pathways that control epithelial cell lineage specification and differentiation. These pathways also contribute to chronic and acute renal disease and cancer, for which novel therapeutics are being developed.  

Cell and systems biology; Biochemistry and structural biology; Genetics/gene regulation, Development, aging, neurobiology; Molecular mechanisms of disease, cancer biology
Research Interests:

Cells encounter starvation during stroke and heart attack, during certain stages of development, and in rapidly growing tumors. Our lab studies how membrane traffic contributes to responses to starvation and normal cell physiology.

Molecular, Cellular, and Developmental Biology
Research Interests:
The goal of the lab is to understand the molecular and neural mechanisms behind behavior and to reflect on the role of the environment on the functioning of neural circuits. Our lab uses both molecular ("omics", genetics, etc.) and neurobiology techniques, such as behavior and in vivo brain imaging. Our goal is to uncover the molecular events underlying the establishment of behavioral states. A main focus of the lab is to study how neurons sense nutrients and how this impacts feeding behavior.

 

Internal Medicine
Research Interests:

Our lab focuses on the genetic determinants of thrombosis, atherosclerosis, and inflammation.

Dermatology/Radiation Oncology
Research Interests:

Our laboratory is interested in molecular mechanisms controlling epidermal growth and differentiation, including how this process is linked to host defense and autoimmunity. For this purpose, we utilize cell biology, organ culture, transgenic animals, genetic linkage analysis, and gene expression profiling.

Cell and Developmental Biology
Research Interests:

Our lab exploits mouse genetics to explore the molecular basis of human disease. We are examining the consequences of targeted loss of function (traditional and conditional knockouts) and gain of function (conventional and BAC transgenics) to understand the developmental regulation of several transcription factors we have cloned over the years (GATA-2, GATA-3, small Mafs and the TR2 and TR4 orphan nuclear receptors), and to unravel their distinct contributions organogenesis.

Neurosurgery/Cell and Developmental Biology
Research Interests:
Develop novel therapies for the malignant brain tumors based on depletion of cancer stem like cells.

 

Internal Medicine/Human Genetics
Research Interests:

Cancer genetics, gastrointestinal cancer, oncogenes, tumor suppressor genes, beta-catenin, Wnt signaling, developmental biology, CDX2, E-cadherin.

Neurology
Research Interests:

The role of growth factors in the pathogenesis and treatment of neurologic disorders.

Pathology
Research Interests:
DNA Repair and Genomic Stability in Mammals. We study how DNA repair prevents cancer, controls development of the immune system, and ensures proper overall mammalian development.

 

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