The Puthenveedu lab studies how receptor signaling pathways are organized in the cell, focusing on GPCRs relevant to drug addiction. We investigate the exciting new idea that signaling is specified not just by the drug/receptor pair, but also by where in the cell the receptors are located. We use innovative microscopy and molecular genetic techniques to directly track receptor trafficking and function in real time in living cells. The long-term goal is to identify factors that will allow us to actively relocate receptors to specific sites in the cell to fine-tune signaling.