People

a b c d e f g h i j k l m n o p q r s t u v w x y z All
(Includes Name, Title, Research Interests)
Assistant Professor of Biomedical Engineering
Accepting new students?
No
DEI Statement:
We are committed to promoting diversity, equity and inclusivity (DEI) in our lab and the University. Our lab has attended training on unconscious bias and crucial conversations as well as participated in strategies to support inclusive climates and under-represented minority student success in STEM departments.
Trainings and Identities:
CMB DEI Task Force, Bystander Training, Gender Bias or Discrimination Training, Self Identified: Hispanic/Latino
Research Interests:

Stem Cells, Genomics, Aging, Muscle

Cell and Developmental Biology
Associate Director of CMB
Research Interests:

Research in the Allen Lab is broadly focused on understanding the mechanisms of growth factor and morphogen signaling in development and disease. Specifically, we study the regulation of Hedgehog signaling during embryonic and postnatal development, as well as adult tissue homeostasis, repair and regeneration. Our research employs a wide range of approaches, including mouse genetics, chicken in ovo electroporations, biochemistry, and cell biology. The long-term goal of this work is to apply insights gained from the study of HH signaling in normal contexts to the treatment of a broad...

Pharmacology
Research Interests:

Our lab uses optical and electrophysiological techniques to study how hormone trafficking, signaling, and release are regulated in neurosecretory cells. We investigate these processes as they relate to stress and stress transduction at the sympatho-adrenal synapse.

Human Genetics, Neurology
Research Interests:

Our objective is to obtain a better understanding of the development and function of neurons and glia in the peripheral nervous system using human genetics, molecular and cellular biology, and zebrafish transgenesis. The major end goal of these studies is to characterize how these cell types are affected in patients with peripheral neuropathies.

David Antonetti
Professor and Scientific Director Kellogg Eye Center
Ophthalmology and Visual Science
Accepting New Students?
Yes
Research Interests:

Diabetic Retinopathy and Stroke

Dr. Peter Arvan
Internal Medicine
Research Interests:

Our lab uses cellular and mouse models to study protein folding and misfolding in pancreatic beta cells (proinsulin) and thyroid epithelial cells (thyroglobulin), in order to discover new treatments for conformational diseases that affect these cells of the endocrine system. Our lab has described the cellular and molecular basis for the human disease known as Mutant INS gene-induced Diabetes of Youth, caused in most cases by expression of misfolded mutant proinsulin.  

Molecular, Cellular, and Developmental Biology
Research Interests:

The effects of sensory experience and sleep on neural circuits, mechanisms underlying nervous system plasticity and memory formation.

Ruth Azaria
Joined CMB:
2021
Mentor:
Dr. Andrew Lieberman
Undergraduate Institution:
University of Michigan
Student Organizations:
Women Excelling More in Math, Engineering, and the Sciences (FEMMES), Biointerfaces Interlaboratory Committees (BIONIC)
Research Interests:

Protein folding, neurodegeneration

MSTP Student
CMB Mentor:
Rami Khoriaty, M.D.
Year:
2017
Assistant Professor of Biological Chemistry
Accepting New Students?
Yes
Research Interests:

Protein quality control at eukaryotic membranes

Jim Bardwell
Professor of Molecular, Cellular & Developmental Biology
Accepting new students?
Yes
Research Interests:

chaperone action, chaperone discovery, directed evolution, nicotine addiction

Associate Professor of Neurology, Angela Dobson and Lyndon Welch Research Professor, Brain Bank Director
Accepting new students?
Maybe
DEI Statement:
Every cell in the body is unique, just as every person is. The body is nothing without cells and their variety, just as the world is made up of people in all their diversity. Here, we believe diversity is to celebrated, equity is a way of living, and inclusion is to be embraced.
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Anti-Racism Training, Gender Bias or Discrimination Training
Research Interests:

RNA stability, RNA binding proteins, neurodegeneration, ALS, FTD

Scott Barolo
Associate Professor of Cell and Developmental Biology; Director of Program in Biomedical Sciences (PIBS)
Accepting new students?
No
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Allyship Training, Anti-Racism Training, Intercultural Training, Gender Bias or Discrimination Training
Research Interests:

Enhancers, gene expression, developmental cell signaling

Molecular & Integrative Physiology
Research Interests:
Research in Dr. Beard's laboratory is focused on systems engineering approaches to understanding the operation of physiological systems in health and disease. Projects include theoretical and experimental analysis of metabolic systems, whole-body cardiovascular mechanics and transport, blood-flow regulation, mechanisms of renal solute transport.

 

MSTP Student
Mentor
Yatrik Shah
Year:
2018
Undergraduate Institution:
UCLA
Research Interests:

I am studying how immunotherapy such as treatment with PDL-1 and CTLA4 affects the immune profile of tumors in mice. We are interested in looking at the differences between responsive and unresponsive tumors.  I am also working on the role of how ER stress and glucose deprivation modulate Stat3 activation.

Mentor:
Karl Desch
Year:
2018
Undergraduate Institution
Bucknell University
Honors
Botanical Society of America Undergraduate Student Research Award Recipient (2017), Phi Sigma member (2018)
Human Genetics
Research Interests:

Discovery of new genes for human developmental brain disorders highlights the genes essential for brain development. The disease mechanisms associated with these genes are modeled using patient induced pluripotent stem cells and mice to understand the associated molecular pathology.

Markus Bitzer
Professor of Internal Medicine
Accepting new students?
Yes
DEI Statement:
I believe that each person has unique strengths and weaknesses which help or limit their ability to achieve their goals. Each team member is supported in unique ways to allow them to achieve their personal goals.
Trainings and Identities:
Immigrant and Multi-racial-Identified
Research Interests:

Kidney disease, system biology, translational research.

Computational Medicine and Bioinformatics, Human Genetics, Medical School
Research Interests:

Our research group aims to combine both computational and wet lab strategies to answer questions related to the transcriptional regulatory control of human genes. We believe that a complex regulatory control determines the fates of individual non-coding regulatory elements and that the integration of diverse genetic, epigenetic, and disease data is the best way to explore this control. Using innovative computational and wet lab approaches the lab both characterizes the function of these regulatory elements as well as examines the effect of genetic variation in these regions.

Cell and Systems Biology, Genomics/Proteomics, Computational Biology, Cancer Biology
Research Interests:
The overarching goal of the lab is to identify putative predictive genomic biomarkers for targeted therapies and understand primary and secondary resistance mechanisms for these therapies. The lab utilizes next generation sequencing strategies for the development and analysis of genomics-driven medicine clinical trials (precision medicine) and genetic characterization of therapeutic resistance. The lab also specializes in using high-throughput functional screens to identify therapeutic targets and molecular strategies to advance for pre-clinical modeling in cell lines and patient-derived...
Pharmacology
Research Interests:

The Brody lab is broadly focused on the molecular signals that underlie cardiac disease onset and progression. We have a specific interest in understanding how intracellular signaling is compartmentalized and regionally controlled by lipid modifications that modulate the function of signaling molecules in various cell types of the heart to control cardiac physiology and pathogenesis. Our laboratory utilizes a combination of mouse genetics, biochemistry, and molecular and chemical biology techniques to gain insight into pathophysiological signaling mechanisms that contribute to human...

Mentor:
Josie Clowney
Year:
2018
Undergraduate Institution:
University of Maryland, Baltimore County
Research Interests:

Understanding gene regulatory networks that govern neuronal circuit formation during development.

Internal Medicine, Mol. Integ. Physiol.
Research Interests:

Our laboratory is interested in understanding how cells use nutrients and how excess nutrient flux, as occurs in obesity, and diabetes, triggers insulin resistance and inflammatory responses. We are also interested in how intrinsic exercise capacity and exercise training can alter metabolism. We use metabolomics profiling and other 'omics technologies to profile metabolism in animals and humans.

Molecular and Cellular Developmental Biology
Research Interests:

The Cadigan lab is interested in signal transduction and gene regulation in Drosophila and mammalian cells. Much of our research is focused on the Wnt/beta-catenin signaling pathway, but we are also exploring other pathways involved in cell specification during development and human disease.

Sally Camper
Margery W. Shaw Distinguished University Professor of Human Genetics
Accepting New Students?
No
Research Interests:

Birth defects research, organogenesis, mouse models of human disease, neuroendocrine development and function, growth insufficiency 

Pharmacology
Research Interests:

We study pathways involved in preserving genome stability as well as mechanisms of resistance to cancer chemotherapy.  

Vern Carruthers
Professor of Microbiology and Immunology
Accepting new students?
Yes
DEI Statement:
The Carruthers lab looks forward to future opportunities to mentor aspiring young scientists pursuing research careers in biomedical research. We place high value on diversity and welcome all individuals regardless of their background, race, religion, gender and gender identity, political views, sexual orientation, or disabilities. We especially encourage dedicated and ambitious individuals who treat others with respect, kindness, inclusion, and understanding to join our team.
Trainings and Identities
MORE Mentor Training, Implicit Bias Training, Disability Awareness Training, Gender Bias or Discrimination Training, First Generation-Identified
Research Interests:

ESCRT, endocytosos, autophagy, genetics, infection

Mol. Integ. Physiol
Research Interests:

Signal transduction pathways used by cytokine receptors and JAK tyrosine kinases; molecular actions of growth hormone; role of SH2-B adapter proteins in regulation of the cytoskeleton, gene expression and cellular differentiation and survival.

Microbiology and Immunology
Research Interests:
The impact of Immune receptor diversity in the response to mutable pathogens and tumors; Immunological memory and transplantation; Mutable vaccines.

 

Molecular and Cellular Developmental Biology
Research Interests:

We are working on protein sorting and quality control in the yeast secretory pathway.

Mentor:
Dr. Yatrik Shah, co-mentor: Dr. Costas Lyssiotis
Year:
2019
Undergraduate Institution:
Emory University
Honors:
Phi Beta Kappa, HHMI EXROP fellowship
Service:
Editor for Journal of Emerging Investigators (JEI)
Research Interests:

Understanding the role of mitophagy in colon cancer iron regulation, and investigating metabolic regulations of ER-mitochondria contact sites in cancer.

Internal Medicine
Research Interests:

The Role of Nuclear Receptors in Obesity/Diabetes-Related Cardiovascular Complications.

Internal Medicine - Hematology/Oncology
Research Interests:

We study the communications between transcription factors that result in epigenetic modifications at super-enhancers of oncogenes. These changes drive the development of normal lymphocytes , but also the generation of cancer stem cells in childhood leukemia. By targeting specific, synthetic lethal interactions responsible for the context dependence of transcription factors in cancer, we might combat the cancer functions of transcription factors without potential adverse consequences of total inhibition.

Michigan Center for Translational Pathology
Research Interests:

Dr. Chinnaiyan's laboratory has focused on functional genomic,proteomic and bioinformatics approaches to study cancer for the purposesof understanding cancer biology as well as to discover clinicalbiomarkers. He and his collaborators have characterized a number ofbiomarkers of prostate cancer including AMACR, EZH2 and hepsin. AMACRis being used clinically across the country in the assessment of cancerin prostate needle biopsies.

Biological Chemistry
Research Interests:

My lab is mainly focusing on biochemical and structural studies on kinetochore assembly, histone chaperones, and Sestrin-mediated mTORC1 regulation.

Mentor:
Ann Miller
Year:
2016
Undergraduate Institution
Eastern Michigan University
Honors:
NSF Graduate Research Fellowship Recipient (2017)
Service:
Science Communication Fellowship with UM’s Museum of Natural History, Females Excelling More in Math, Engineering, and Science (FEMMES), Lean in for Graduate Students, Association for Women in Science, CMB Career Committee.
Research Interests:

Using optogenetics, investigate the spatiotemporal regulation of small GTPase RhoA and how it orchestrates actin cytoskeletal dynamics responsible for junctional remodeling and cytokinesis in vertebrate epithelial tissues.

Internal Medicine
Research Interests:

Our lab is interested in the proteolytic ECM remodeling of adipose tissues in development and obesity. Using 3-D adipocyte differentiation model and a series of genetically modified mice, we aim to define a molecular mechanism that links ECM remodeling to the regulation of organ function in development and diseases.

Research Interests:

How is specificity determined between motor proteins and cargo?
How are the activities of multi-motor complexes regulated? 
What are the molecular consequences of neurodegenerative disease-causing mutations?

Josie Clowney
Assistant Professor of Molecular, Cellular, and Developmental Biology
Accepting new students?
Yes
DEI Statement:
I try to foster a culture of abundance in the lab and create an environment in which trainees are able to be their "whole selves." I am also working to increase equity in how undergraduates obtain research experience.
Trainings and Identities:
MORE Mentor Training, Bystander Training, HHMI Inclusive Mentoring Training
Research Interests:

development, olfaction, neural circuits, genome evolution, sexual dimorphism

Sam Collie
Joined CMB:
2021
Faculty Mentor:
Dr. Carole Parent
Undergraduate Institution:
Millsaps College
Research Interests:

Understanding the role of NETs in neutrophil-mediated immune functions as well as the intercellular signaling cascade surrounding this process. 

Internal Medicine/Micro and Imm
Research Interests:
Molecular Mechanisms of HIV Disease Pathogenesis.

 

Mentor:
Dr. Melanie Ohi
Year:
2019
Undergraduate Institution:
Truman State University
Research Interests:

 I am studying the H. pylori virulence factor vacuolating cytotoxin A (VacA). Using single-particle cryo-EM, I am determining VacA's pore-form and characterizing its membrane interactions. 

Professor, Department of Otolaryngology-Head and Neck Surgery
Research Interests:

The Corfas Laboratory is interested in understanding the roles that interactions between neurons and glia-the two fundamental cell types of the nervous system-play in nervous system development, function and maintenance and in defining the molecular signals that orchestrate these interactions.

Adele Correia
Joined CMB:
2021
Mentor:
Dr. Andrew Lieberman
Research Interests:

I study the mechanisms of neurodegeneration in Niemann-pick type C disease, an autosomal recessive lysosomal storage disorder

G. Carl Huber Professor and Chair, Cell & Developmental Biology
Accepting new students?
No
DEI Statement:
Diversity is essential to achieve success, viewed from a broad array of vantage points. My laboratory has a diverse roster, and strives for a culture of inclusiveness. I am also proud of the efforts and program that we have put in place in my home department, CDB, to improve diversity and climate and, moreover, I am also proud of the fact that we are aware of how much more we need to do. Importantly, I believe that it is eminently possible to be successful with regards to diversity, equity, inclusiveness and climate while pursuing our main mission as a unit, which is research, discovery, and training.
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Gender Bias or Discrimination Training, Leading the department I chair, CDB, regarding DEI and climate issues., first-generation-identified (college graduate)
Research Interests:

Tissue homeostasis, cell differentiation, genetic skin diseases, cancer, nucleus

Pharmacology
Research Interests:

Our research seeks to manipulate signaling pathways in T cells to understand their behavior. We are especially interested in how T cell recognize and respond to antigen. By applying our findings in the setting of cancer we aim to develop new immunotherapy strategies.

 

Mentor:
Manoj Puthenveedu
Year:
2016
Undergraduate Institution:
Penn State University
Honors:
NSF GRFP awardee, ARCS foundation Pittsburgh Chapter award recipient.
Service:
Social committee (Carnegie Mellon), Graduate sciences teaching club (Carnegie Mellon)
Research Interests:

I study the biosynthetic trafficking of G-protein-coupled receptors (GPCRs). GPCR localization to the the cell surface is critical for functional coupling to both extracellular agonists and G-protein effectors on the plasma membrane. Despite the functional importance of GPCR localization to the plasma membrane, relatively little is known about the biosynthetic trafficking of these receptors to the cell surface. I would like to understand how the trafficking of these receptors to the cell surface is regulated and how we can target receptors to the surface to increase signaling. 

Urology
Research Interests:
Proteolytic processing of tumor cells in prostate cancer metastasis. Regulation of novel E2F1 target genes following disruption of the Rb/E2F pathway in human cancer.

 

Mentor:
Ryan Baldridge
Year:
2018
Undergraduate Institution:
University of California, Berkeley
Teaching Experience:
Undergraduate Intern for the Seattle Children's Research Institute's Science Adventure Lab program
Service:
Volunteer at Tiny Lions (part of the Humane Society of Huron Valley); Mentor for InnoWorks Camp
Research Interests:

Protein Quality Control Pathways

Assistant Professor, Molecular and Cellular Developmental Biology
Accepting New Students?
Yes
Research Interests:

Cytoskeleton, Motor proteins, Microtubules, Dynein

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