Protein quality control at eukaryotic membranes
chaperone action, chaperone discovery, directed evolution, nicotine addiction
RNA stability, RNA binding proteins, neurodegeneration, ALS, FTD
Enhancers, gene expression, developmental cell signaling
I am studying how immunotherapy such as treatment with PDL-1 and CTLA4 affects the immune profile of tumors in mice. We are interested in looking at the differences between responsive and unresponsive tumors. I am also working on the role of how ER stress and glucose deprivation modulate Stat3 activation.
Neurogenetics, neural development, chromatin biology, cell fate, mouse and human brain organoids
Kidney disease, system biology, translational research.
Our research group aims to combine both computational and wet lab strategies to answer questions related to the transcriptional regulatory control of human genes. We believe that a complex regulatory control determines the fates of individual non-coding regulatory elements and that the integration of diverse genetic, epigenetic, and disease data is the best way to explore this control. Using innovative computational and wet lab approaches the lab both characterizes the function of these regulatory elements as well as examines the effect of genetic variation in these regions.
signal transduction, cardiac hypertrophy, heat failure, post-translational modifications
Understanding gene regulatory networks that govern neuronal circuit formation during development.
Our laboratory is interested in understanding how cells use nutrients and how excess nutrient flux, as occurs in obesity, and diabetes, triggers insulin resistance and inflammatory responses. We are also interested in how intrinsic exercise capacity and exercise training can alter metabolism. We use metabolomics profiling and other 'omics technologies to profile metabolism in animals and humans.