Protein quality control at eukaryotic membranes
chaperone action, chaperone discovery, directed evolution, nicotine addiction
RNA stability, RNA binding proteins, neurodegeneration, ALS, FTD
Enhancers, gene expression, developmental cell signaling
I am studying how immunotherapy such as treatment with PDL-1 and CTLA4 affects the immune profile of tumors in mice. We are interested in looking at the differences between responsive and unresponsive tumors. I am also working on the role of how ER stress and glucose deprivation modulate Stat3 activation.
Discovery of new genes for human developmental brain disorders highlights the genes essential for brain development. The disease mechanisms associated with these genes are modeled using patient induced pluripotent stem cells and mice to understand the associated molecular pathology.
Kidney disease, system biology, translational research.
Our research group aims to combine both computational and wet lab strategies to answer questions related to the transcriptional regulatory control of human genes. We believe that a complex regulatory control determines the fates of individual non-coding regulatory elements and that the integration of diverse genetic, epigenetic, and disease data is the best way to explore this control. Using innovative computational and wet lab approaches the lab both characterizes the function of these regulatory elements as well as examines the effect of genetic variation in these regions.
The Brody lab is broadly focused on the molecular signals that underlie cardiac disease onset and progression. We have a specific interest in understanding how intracellular signaling is compartmentalized and regionally controlled by lipid modifications that modulate the function of signaling molecules in various cell types of the heart to control cardiac physiology and pathogenesis. Our laboratory utilizes a combination of mouse genetics, biochemistry, and molecular and chemical biology techniques to gain insight into pathophysiological signaling mechanisms that contribute to human...
Understanding gene regulatory networks that govern neuronal circuit formation during development.
Our laboratory is interested in understanding how cells use nutrients and how excess nutrient flux, as occurs in obesity, and diabetes, triggers insulin resistance and inflammatory responses. We are also interested in how intrinsic exercise capacity and exercise training can alter metabolism. We use metabolomics profiling and other 'omics technologies to profile metabolism in animals and humans.