

Protein Quality Control Pathways
Cytoskeleton, Motor proteins, Microtubules, Dynein

Our lab concentrates on the molecular characterization of common and rare variants in genes associated with bleeding or thrombosis risk in humans. Through the study of large cohorts of human subjects, we and others have identified genetic variants associated with altered risk for disease. In our lab, we employ molecular and cellular techniques, such as mammalian cell culture, proteomic profiling, genome-wide CRISPR mediated knock-out screens, and mutagenesis libraries to functionally characterize the altered molecular genetic mechanisms contributing to disease risk.

Hedgehog-driven cancers, viral oncogenesis, non-melanoma skin cancers

Developmental biology, stem cells, epigenetics, kidney disease

Protein therapeutics - evolution, delivery, and design

Membrane traffic, Cell polarity, Protein interactions, Yeast, Organoids

Osteoimmunology

Nutriepigenetics, metabolism, processed food, feeding behavior