The goal of our laboratory is to understand the molecular mechanisms underlying normal and abnormal mammalian eye development. The approaches we employ include mouse models, functional genomics, and cell culture systems.
Genetics, genomics, smooth muscle cells, vascular diseases, translational science
A long standing goal of our research is to understand how neuronal growth and sprouting is regulated in the mammalian nervous system during development, adult neuronal plasticity, and following injury (i.e. spinal cord injury, traumatic brain injury, stroke or multiple sclerosis). We pursue a mouse genetic approach to study the function of different classes of proteins that are known to regulate neuronal growth, including members of the Semaphorin family and their cognate receptors (Neuropilins and Plexins), myelin-associated inhibitors and their receptors. The Nogo Receptors NgR1 and NgR2...
I work in a beta-cell biology and diabetes lab. We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.
Thrombosis, hemostasis, endothelial cells, protein engineering, ER-Golgi trafficking.
stem cells, retina, central nervous system, regeneration
The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging