The goal of our laboratory is to understand the molecular mechanisms underlying normal and abnormal mammalian eye development. The approaches we employ include mouse models, functional genomics, and cell culture systems.
Genetics, genomics, smooth muscle cells, vascular diseases, translational science
We are interested in the chemistry, biology and molecular engineering of microbes. The current focus lies on understanding and engineering megadalton protein organelles involved in stress resistance, nutrient utilization and pathogenicity and on the discovery and characterization of novel enzymatic transformations and bioactive compounds. Based on our fundamental discoveries regarding bacterial metabolism and cell biology, we utilize protein and metabolic engineering to create the next generation of living diagnostics and therapeutics, programmable nanomaterials and nanoreactors. Our...
A long standing goal of our research is to understand how neuronal growth and sprouting is regulated in the mammalian nervous system during development, adult neuronal plasticity, and following injury (i.e. spinal cord injury, traumatic brain injury, stroke or multiple sclerosis). We pursue a mouse genetic approach to study the function of different classes of proteins that are known to regulate neuronal growth, including members of the Semaphorin family and their cognate receptors (Neuropilins and Plexins), myelin-associated inhibitors and their receptors. The Nogo Receptors NgR1 and NgR2...
I work in a beta-cell biology and diabetes lab. We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.
Thrombosis, hemostasis, endothelial cells, protein engineering, ER-Golgi trafficking.
Molecular cytogenetics and the molecular biology of human disease.
We investigate the cellular and molecular mechanisms underlying retina regeneration in zebrafish and neuromuscular synapse regeneration in mice. We anticipate this research will suggest novel strategies for stimulating retinal repair in people suffering from blinding eye diseases and enhance motor function in people suffering from motor neuron disease and age-related sarcopenia.
The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging
Structural dynamics of HIV-1 RNA
Diabetes metabolism, and neuronal circuits