Our lab studies how epigenetic and metabolic dysregulation influence the development and biology of pediatric brain tumors. My work focuses on a novel epigenetic modifier, EZHIP, which is overexpressed in a subtype of childhood brain cancer known as PF-A ependymomas. EZHIP inhibits polycomb-mediated trimethylation at histone H3 lysine 27 (H3K27me3), a transcriptionally repressive chromatin modifying mark. EZHIP overexpression gives rise to a global reduction in H3K27me3 marks throughout the genome that is poorly prognostic. My project aims to understand the mechanisms regulating EZHIP...
Investigating the role of membrane trafficking in development
Dr. Gary D. Hammer, M.D., Ph.D. is a medical endocrinologist specializing in the treatment of adrenal and gonadal diseases. Work in his laboratory has focused on the mechanisms by which signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on the dysregulated growth of adrenocortical stem cells in development and cancer.
Work in the Hanson lab addresses fundamental questions about how cells regulate the structure
and organization of their membranes. We use biochemical, cellular, and imaging approaches to
study molecular reactions that control trafficking and organelle function with a particular interest
in how the ESCRT machinery acts to remodel and repair membranes. Available projects are
relevant to understanding the pathophysiology of neurodegenerative disorders, infectious
disease, cancer and more.
Our goal is to understand how human pluripotent stem cells generate and interpret the chemical and physical signals that allow them to self-organize into spatial structures consisting of multiple cell types in vitro, and, by extension to the embryo, in vivo. By combining quantitative live-cell measurements and engineering tools such as micropatterning with predictive mathematical models we can answer currently intractable questions in developmental and stem cell biology.