Epigenetics, chromatin modifications, dosage compensation, embryology, and stem cell biology.
The focus of the research in my laboratory is the use of mouse models 1) to understand the mechanisms that lead to birth defects affecting caudal structures in humans, and 2) to understand the mechanisms by which telomere dysfunction causes distinct phenotypes in humans. Prior work in my laboratory has focused on genetically characterizing spontaneous mouse mutants as a platform to understand how disruption of key cellular and developmental processes can lead to structural birth defects and other diseases in humans.
Our laboratory studies the biology of prostate cancer skeletal metastases through a variety of methods. Our current work focuses on examining bone morphogenetic proteins (BMPs) that work through SMAD transcription factors, exploring a signal transduction factor that diminishes prostate cancer metastases, and investigating how interleukin-6 stimulates the androgen receptor in prostate cancer cells.
hematopoiesis; erythropoiesis; globin switching, secretory pathway, CRISPR screens
Studying the mechanism of nuclear pore complex formation in neurons and the role of torsinA with regards to nuclear pore biology
microbiome, structural biology, glycoside hydrolases, Bacteroides, starch
We use genomics and proteomics to study signaling networks regulating yeast cell growth, cell polarity and cell cycle progression. These networks serve as orthologous models of pathways relevant for: 1) fungal infections of immunocompromised individuals; 2) tumor cell metastasis; 3) cancer research.
Experimental research activities directed at understanding the cellular and molecular mechanisms of cytokine networks that are operative in different immune/inflammatory reactions and host defenses represent the major research efforts in the laboratory.
Identify and examine the homeostatic regulation of mu-opioid receptor recycling and study its regulatory signaling pathway. Study and identify the cellular molecules required for opioid receptor trafficking and signaling in response to various neuropeptides.