Epigenetics, chromatin modifications, dosage compensation, embryology, and stem cell biology.
The focus of the research in my laboratory is the use of mouse models 1) to understand the mechanisms that lead to birth defects affecting caudal structures in humans, and 2) to understand the mechanisms by which telomere dysfunction causes distinct phenotypes in humans. Prior work in my laboratory has focused on genetically characterizing spontaneous mouse mutants as a platform to understand how disruption of key cellular and developmental processes can lead to structural birth defects and other diseases in humans.
hematopoiesis; erythropoiesis; globin switching, secretory pathway, CRISPR screens
Studying the mechanism of nuclear pore complex formation in neurons and the role of torsinA with regards to nuclear pore biology
microbiome, structural biology, glycoside hydrolases, Bacteroides, starch
We use genomics and proteomics to study signaling networks regulating yeast cell growth, cell polarity and cell cycle progression. These networks serve as orthologous models of pathways relevant for: 1) fungal infections of immunocompromised individuals; 2) tumor cell metastasis; 3) cancer research.
Experimental research activities directed at understanding the cellular and molecular mechanisms of cytokine networks that are operative in different immune/inflammatory reactions and host defenses represent the major research efforts in the laboratory.