Investigating the role of AMPylation on Hsp70 chaperones in Neurodegenerative Disease models
The rapid evolution of RNA viruses makes them particularly challenging targets for vaccines and antiviral drugs. However, a clearer understanding of their unique evolutionary dynamics may suggest novel approaches for control. Our research objective is to understand mechanisms of viral evolution as they relate to transmission and pathogenesis in infected hosts. We study aspects of evolutionary theory in the context of the host-pathogen interface using molecular virology, small animal models, and sequence data from clinical specimens.
Ischemic stroke, neurodegenerative disease, vascular biology of the CNS, fibrotic disease
Dr. Lei is on the steering committee of the NCI Cancer Moonshot Immuno-Oncology Translational Network. He is a recipient of the NIH Rising Stars award. His group pioneers at the identification of oncogenic suppressors of the innate immune system. Pattern Recognition Receptors (PPRs) constitute the first line of defense against “non-self” antigens such as tumor neoepitopes. With the characterization of new PRR families, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-I-like receptors (RLRs), and cGAS-STING-mediated cytoplasmic DNA-sensing molecules, novel regulatory...
Our laboratory focuses on the molecular and cellular basis of neural control of breathing, and how it goes awry in diseases. By molecular and genetic dissection of the breathing control circuit, we study the function of neural populations and pathways underlying breathing rhythms and behaviors, and the pathophysiology of diseases with breathing abnormality.
Mechanobiology and mechanotransduction, cell migration, clathrin-mediated endocytosis, cytoskeleton, bottom-up synthetic biology
stem cells, regeneration, gene therapy, cancer