The goals of our research program are to determine the molecular mechanisms by which extracellular signals regulate mesenchymal cell fate decisions, and to improve our understanding of adipocyte metabolism. Mesenchymal stem cells have the capacity to differentiate into a number of cell types, including adipocytes, osteoblasts and myocytes.
Interested in human ovarian folliculogenesis and fertility preservation
Investigating the function of paternally-inherited histones during early embryogenesis.
Developing a device to simultaneously measure NADH generation and oxygen consumption in mitochondria in order to investigate the role of metabolic intermediates in bioenergetics. The data collected will be used to develop a computer model of the system.
My research focuses on investigating Notch cofactors that may regulate Notch signaling in T-cell Acute Lymphoblastic Leukemia
Understanding the role of nuclear hormone receptors in the radiosensitization of breast cancers.
Using cell lines and neuronal models to investigate molecular mechanisms of Ubiquilin-2 (UBQLN2) regulation in normal cellular function and ALS caused by UBQLN2 mutations.
Rho GTPases, cell-cell junctions, cytokinesis, cytoskeleton, mechanotransduction
hypothalamus, brainstem, obesity, diabetes, leptin