cell migration, signaling, immune responses, cancer invasion
Polyglutamine neurodegenerative disease; Spinocerebellar Ataxia type 3; RNA interference as potential therapy including studies of polyglutamine diseases and Alzheimer's disease; Protein quality control in normal brain function in disease.
Photoreceptor Cell Biology, Membrane Trafficking, Ciliogenesis, Inherited Retinal Disease
Using biochemical and microscopy approaches with cell culture and mouse models, I am fascinated to reveal nuclear Keratin’s role in DNA damage response mechanisms.
Our goal is to identify and investigate genetic mechanisms that are likely to be important for aging and age-related disease in humans by focusing on equivalent, conserved processes in the fruit fly, Drosophila melanogaster. Currently we are studying neuronally-expressed genes involved in linking diet, obesity, and immune function with aging and aging-related disease.
Genetics, eye disease, developmental disorders
The Puthenveedu lab studies how receptor signaling pathways are organized in the cell, focusing on GPCRs relevant to drug addiction. We investigate the exciting new idea that signaling is specified not just by the drug/receptor pair, but also by where in the cell the receptors are located. We use innovative microscopy and molecular genetic techniques to directly track receptor trafficking and function in real time in living cells. The long-term goal is to identify factors that will allow us to actively relocate receptors to specific sites in the cell to fine-tune signaling.