Immunity to Virus Infections and Cancers
We study how organisms use gases (CO, CO2, CH4) in metabolism and in metabolic regulation, how metals catalyze reactions and how thiol/disulfide redox switches regulate the activity of enzymes, ion channels and transcriptional regulators. We target systems that are important in human health, environmental biology, and biological energy conversion.
My lab is interested in the molecular mechanisms that define how the combinatorial logic of histone modifications and its dynamic interactions with histone binding proteins encodes stable and heritable patterns of gene expression. We take a multidisciplinary perspective that synthesizes genetics, biochemistry and biophysical approaches to capture cellular processes across different spatial and temporal regimes.
I am interested in understanding and identifying mechanisms of resistance to anti-neoplastic drugs. My work focuses on protein phosphatase 2A (PP2A) - a key regulator of signaling pathways implicated in drug resistance mechanisms.
stem cells, organoids, retina, epigenetics, epitranscriptomics
How the regulation of Semaphorin and Plexin signaling affect brain development.
Evasion of enteric pathogens to the host immune system, and conversely, host immune system resistance against infection by enteric pathogens.
Dr. Russell is studying mechanisms of cardiac and skeletal myofibril assembly, alignment and structural support, topics central to the pathophysiology of, and development of new therapies for, heart failure, myopathy and muscular dystrophy. His laboratory is currently using cell culture as well as mouse and zebrafish model systems to determine the functions of a novel pair of genes, obscurin and obscurin-like 1, that have been cloned and characterized in his laboratory.
Controllability of cell fate decision making. Cell reprogramming and transcription factor delivery modalities.