People

a b c d e f g h i j k l m n o p q r s t u v w x y z All
(Includes Name, Title, Research Interests)
Malini Raghavan
Professor of Microbiology and Immunology
Accepting new students?
Yes
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Allyship Training, Anti-Racism Training, CMB DEI Task Force, Intercultural Training, First Generation-Identified
Research Interests:

Immunity to Virus Infections and Cancers

Biological Chemistry
Research Interests:

We study how organisms use gases (CO, CO2, CH4) in metabolism and in metabolic regulation, how metals catalyze reactions and how thiol/disulfide redox switches regulate the activity of enzymes, ion channels and transcriptional regulators. We target systems that are important in human health, environmental biology, and biological energy conversion.

Biological Chemistry
Research Interests:

My lab is interested in the molecular mechanisms that define how the combinatorial logic of histone modifications and its dynamic interactions with histone binding proteins encodes stable and heritable patterns of gene expression. We take a multidisciplinary perspective that synthesizes genetics, biochemistry and biophysical approaches to capture cellular processes across different spatial and temporal regimes. 

Brynne Raines
Faculty Mentor:
Goutham Narla, MD, PhD
Year:
2019
Undergraduate Institution:
University of Michigan - Ann Arbor
Service:
Community Outreach for the Society of Black Brain and Behavioral Sciences, Females Excelling More in Math, Engineering, and Science (FEMMES), & Reviewer for Journal of Emerging Investigators (JEI)
Honors:
Outstanding Research Staff Award (2017), Rackham Merit Fellowship (2019), &Regents Fellowship (2020)
Research Interests:

I am interested in understanding and identifying mechanisms of resistance to anti-neoplastic drugs. My work focuses on protein phosphatase 2A (PP2A) - a key regulator of signaling pathways implicated in drug resistance mechanisms. 

Rajesh Rao
Leonard G. Miller Professor of Ophthalmology & Visual Sciences, Associate Professor of Ophthalmology & Visual Sciences, and Pathology
Accepting new students?
Yes
Research Interests:

stem cells, organoids, retina, epigenetics, epitranscriptomics

Mentor:
Margaret Westfall
Year:
2016
Undergraduate Institution:
University of Maryland, Baltimore County
Service:
Volunteer for Chinmaya Organization for Rural Development (CORD), volunteer for Females Excelling More in Mathematics Engineering and Science (FEMMES) capstone, participant in Women In Science and Engineering (WISE), participant and former executive board member of Association for Women In Science (AWIS), Michigan DNA Day pharmacogenomics lecture.
Research Interests:
Our lab tests whether phosphorylation of the cardiac contractile apparatus acts as both an accelerator and a brake for pump performance and whether chronic phosphorylation contributes to heart failure. These ideas are tested using mouse models expressing either a phospho-mimetic or –null substitution at specific phosphorylation sites within contractile proteins. Both structural remodeling and functional performance are studied to determine the impact of these substitutions. Recent work led to a focus on sarcomere- mitochondrial communication and the contribution mitochondrial reactive oxygen species to the development and progression of heart failure caused by a phospho-mimetic substitution in a molecular switch contractile protein. The rationale for this idea is that a critical component of the cardiac contractile apparatus, myosin, uses the majority of mitochondria-derived ATP to drive cardiac pump function. Intuitively, then, impairments in mitochondrial function and subsequent output of reactive oxygen species may play a role in development and progression of heart failure. Indeed, alterations in mitochondrial function (specifically overproduction of reactive oxygen species) are linked to many cardiovascular diseases, including heart failure. Our lab aims to develop a clear understanding of how changes in a sarcomeric protein can trigger changes in mitochondrial redox to potentially cause heart failure.
Radiation Oncology
Research Interests:

Genetic basis of therapeutic resistance in glioblastoma and identification of therapeutic targets that reverses resistance to standard of care therapies.

Tony Robinson
Faculty Mentor
Roman Giger, PhD
Year:
2019
Undergraduate Institution:
University of Michigan-Dearborn
Research Interests:

How the regulation of Semaphorin and Plexin signaling affect brain development.

Faculty Mentor:
Peter Freddolino
Year:
2021
Undergraduate Institution:
Wayne State University
Research Interests:

 Evasion of enteric pathogens to the host immune system, and conversely, host immune system resistance against infection by enteric pathogens.

Mol. and Integ. Physiol
Research Interests:

Cell signaling and molecular mechanism of obesity and type 2 diabetes.

Department of Pediatrics and Communicable Diseases
Research Interests:

Dr. Russell is studying mechanisms of cardiac and skeletal myofibril assembly, alignment and structural support, topics central to the pathophysiology of, and development of new therapies for, heart failure, myopathy and muscular dystrophy. His laboratory is currently using cell culture as well as mouse and zebrafish model systems to determine the functions of a novel pair of genes, obscurin and obscurin-like 1, that have been cloned and characterized in his laboratory.

Charles Ryan
MSTP Student
Faculty Advisor:
Indika Rajapakse, Ph.D.
Undergraduate Institution:
Syracuse University
Honors:
Department Award for Exceptional Performance in Biochemistry
Service:
Medical student tutoring
Research Interests:

Controllability of cell fate decision making. Cell reprogramming and transcription factor delivery modalities.