The Schnell lab investigates multiscale cellular physiology mechanisms. We develop models for the analysis of biochemical reactions and biophysical processes. We used these models to investigate a variety of cell physiology problems. We are particularly interested in investigating the molecular mechanisms of pancreatic b-cells turnover and dysfunction in diabetes, the dynamics of metabolic pathways in cancer cells and the mechanisms of protein misfolding and aggregation in conformational diseases.
Using a human-based model organoid systems to recapitulate early embryonic development in vitro. Particularly interested in using these models to study the regulatory signaling pathways during lung development
Epigenetics, Heterochromatin, S pombe
CRISPR Screening, LDL uptake
tissue engineering, reproduction, biomaterials
Research in the Singer lab is focused on understanding the influence of diet-induced obesity on hematopoiesis and the generation of activated macrophages that lead to metabolic disease.Current projects in the laboratory focus on (1) sexually dimorphic inflammatory responses responses to high fat diet and (2) mechanisms driving hematopoietic stem cell myeloid differentiation after high fat diet exposure. This work in mouse models uses bone marrow transplantation, stem-cell analysis techniques, and metabolic profiling.
protein structure-function, antiviral proteins, virulence factors, biosynthetic enzymes
G protein and Receptor Mediated Signal Transduction
The Role of Mitophagy in Diabetes
All forms of diabetes share the common etiology of insufficient insulin release from pancreatic islet beta cells to meet peripheral insulin demand. Beta cells require mitochondrial function in order to maintain proper glucose stimulated insulin release. Our lab focuses on the molecular and genetic regulation of the mitochondrial life cycle, with a focus on mitophagy, a pathway to dispose of unhealthy or damaged mitochondria. Our studies also focus on novel genetic targets affecting the mitophagy pathway, which are also associated with diabetes in...
translational research, breast cancer, radiosensitization