The Schnell lab investigates multiscale cellular physiology mechanisms. We develop models for the analysis of biochemical reactions and biophysical processes. We used these models to investigate a variety of cell physiology problems. We are particularly interested in investigating the molecular mechanisms of pancreatic b-cells turnover and dysfunction in diabetes, the dynamics of metabolic pathways in cancer cells and the mechanisms of protein misfolding and aggregation in conformational diseases.
Using a human-based model organoid systems to recapitulate early embryonic development in vitro. Particularly interested in using these models to study the regulatory signaling pathways during lung development
Epigenetics, Heterochromatin, S pombe
CRISPR Screening, LDL uptake
tissue engineering, reproduction, biomaterials
Research in the Singer lab is focused on understanding the influence of diet-induced obesity on hematopoiesis and the generation of activated macrophages that lead to metabolic disease.Current projects in the laboratory focus on (1) sexually dimorphic inflammatory responses responses to high fat diet and (2) mechanisms driving hematopoietic stem cell myeloid differentiation after high fat diet exposure. This work in mouse models uses bone marrow transplantation, stem-cell analysis techniques, and metabolic profiling.
We investigate biological function and mechanism at the molecular level by developing a structure-based understanding of proteins and macromolecular complexes. The lab studies biosynthetic pathways for natural products, proteins of pathogenic viruses, and host proteins that defend against viral pathogens.
G protein coupled receptors (GPCRs) form a large family of cell surface receptors responsible for triggering cellular responses to a variety of extracellular stimuli including drugs such as opiates, and hormones such as adrenaline, serotonin or acetylcholine. We focus on analysis of G protein signal transduction pathways at a molecular, cellular and translational level with the goal of understanding how these pathways control physiology and disease. We use a broad range of approaches including biochemistry, molecular biology, live cell imaging technologies and cutting edge genetic...
The Role of Mitophagy in Diabetes
All forms of diabetes share the common etiology of insufficient insulin release from pancreatic islet beta cells to meet peripheral insulin demand. Beta cells require mitochondrial function in order to maintain proper glucose stimulated insulin release. Our lab focuses on the molecular and genetic regulation of the mitochondrial life cycle, with a focus on mitophagy, a pathway to dispose of unhealthy or damaged mitochondria. Our studies also focus on novel genetic targets affecting the mitophagy pathway, which are also associated with diabetes in...
The Speers laboratory is interested in “bench to bedside” research that includes basic mechanistic studies, translational pre-clinical studies, and clinical research. As PI or co-Investigator on several university-, industry-, private foundation- and NIH-funded grants, we remain active in the radiation and breast cancer research arena by looking for more effective, targeted therapies for women with breast cancer. These targeted therapies include PARP-inhibitors, CDK 4/6 inhibitors, and androgen receptor antagonists as agents for radiosensitization. We have also utilized kinome screens to...