People

a b c d e f g h i j k l m n o p q r s t u v w x y z All
(Includes Name, Title, Research Interests)
Molecular & Integrative Physiology
Research Interests:

The Schnell lab investigates multiscale cellular physiology mechanisms. We develop models for the analysis of biochemical reactions and biophysical processes. We used these models to investigate a variety of cell physiology problems. We are particularly interested in investigating the molecular mechanisms of pancreatic b-cells turnover and dysfunction in diabetes, the dynamics of metabolic pathways in cancer cells and the mechanisms of protein misfolding and aggregation in conformational diseases.

Biological Chemistry
Research Interests:

Molecular mediators of stress and anxiety; regulation and role of CRH, the CRH receptors and CRH-binding protein in stress; mechanisms of transcriptional regulation; transgenic mice.

Internal Medicine
Research Interests:
Our lab studies mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development.

 

MSTP Student
Mentor:
Jason Spence, Ph.D.
Year in CMB:
2019
Undergraduate Institution:
University of Michigan - Ann Arbor
Research Interests:

Using a human-based model organoid systems to recapitulate early embryonic development in vitro. Particularly interested in using these models to study the regulatory signaling pathways during lung development 

Mentor:
Dr. Kaushik Ragunathan
Year:
2019
Undergraduate Institution:
University of Wisconsin-Madison
Service:
AWIS
Honors:
National Science Foundation (NSF) Honorable Mention
Research Interests:

Epigenetics, Heterochromatin, S pombe

Candilianne Serrano Zayas
Mentor:
Dr. David Ginsburg and Dr. Brian Emmer
Year:
2017
Undergraduate Institution:
Universidad Metropolitana Cupey and Case Western Reserve University
Awards/Honors:
Rackham Merit Fellowship, CMB Training Grant (2018-2019), and HHMI Gilliam Fellow
Research Interests:

CRISPR Screening, LDL uptake

Molec & Integrative Physiology
Research Interests:
The major goal of our research program is to determine the molecular mechanisms by which oxygen sensing transcription factors regulate gastrointestinal homeostasis, inflammation and cancer. Cellular oxygen level is an important systemic signal that modulates metabolic activities and disease in the liver and intestine. Low cellular oxygen also referred to as hypoxia is observed in several gastrointestinal diseases such as non-alcoholic and alcoholic fatty liver disease, inflammatory bowel disease and liver and colon cancers.

 

Professor of Pediatrics and Henry and Mala Dorfman Family Professor
Accepting new students?
Yes
Research Interests:

hematology, zebrafish, genome editing, genetics, modifier genes

Madeline Shay
Joined CMB:
2021
Mentor:
Dr. Nicole Koropatkin
Research Interests:

Structural biology, microbiomes, host-microbe interactions

Ariella Shikanov
Associate Professor of Biomedical Engineering
Accepting new students?
Yes
Trainings and Identities
MORE Mentor Training, Implicit Bias Training, Bystander Training, Gender Bias or Discrimination Training
Research Interests:

tissue engineering, reproduction, biomaterials

Pediatrics
Research Interests:

Research in the Singer lab is focused on understanding the influence of diet-induced obesity on hematopoiesis and the generation of activated macrophages that lead to metabolic disease.Current projects in the laboratory focus on (1) sexually dimorphic inflammatory responses responses to high fat diet and (2) mechanisms driving hematopoietic stem cell myeloid differentiation after high fat diet exposure. This work in mouse models uses bone marrow transplantation, stem-cell analysis techniques, and metabolic profiling.

Janet Smith, Ph.D.
Department of Biological Chemistry
Research Interests:

We investigate biological function and mechanism at the molecular level by developing a structure-based understanding of proteins and macromolecular complexes. The lab studies biosynthetic pathways for natural products, proteins of pathogenic viruses, and host proteins that defend against viral pathogens.

Pharmacology Department
Research Interests:

G protein coupled receptors (GPCRs) form a large family of cell surface receptors responsible for triggering cellular responses to a variety of extracellular stimuli including drugs such as opiates, and hormones such as adrenaline, serotonin or acetylcholine.  We focus on analysis of G protein signal transduction pathways at a molecular, cellular and translational level with the goal of understanding how these pathways control physiology and disease. We use a broad range of approaches including biochemistry, molecular biology, live cell imaging technologies and cutting edge genetic...

Soleimanpour, Arash (Scott)
Internal Medicine
Research Interests:

The Role of Mitophagy in Diabetes 

All forms of diabetes share the common etiology of insufficient insulin release from pancreatic islet beta cells to meet peripheral insulin demand. Beta cells require mitochondrial function in order to maintain proper glucose stimulated insulin release.  Our lab focuses on the molecular and genetic regulation of the mitochondrial life cycle, with a focus on mitophagy, a pathway to dispose of unhealthy or damaged mitochondria. Our studies also focus on novel genetic targets affecting the mitophagy pathway, which are also associated with diabetes in...

Kaitlyn Speckhart
Mentor:
Dr. Billy Tsai
Year:
2020
Undergraduate Institution:
Blackburn College
Research Interests:

Understanding the mechanisms of HPV cellular entry.

Radiation Oncology
Research Interests:

The Speers laboratory is interested in “bench to bedside” research that includes basic mechanistic studies, translational pre-clinical studies, and clinical research. As PI or co-Investigator on several university-, industry-, private foundation- and NIH-funded grants, we remain active in the radiation and breast cancer research arena by looking for more effective, targeted therapies for women with breast cancer. These targeted therapies include PARP-inhibitors, CDK 4/6 inhibitors, and androgen receptor antagonists as agents for radiosensitization. We have also utilized kinome screens to...

Department of Internal Medicine
Research Interests:
Stem cells, developmental biology

 

Professor of Microbiology and Immunology
Accepting new students?
No
DEI Statement:
Research has shown that diverse teams are more creative and productive. Our lab thus welcomes the opportunity to mentor students and postdocs with diverse backgrounds who share our enthusiasm for science in general and especially virology! We are dedicated to high quality research in an environment where we are respectful and kind to each other, and in which motivated people with diverse backgrounds can succeed!
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Bystander Training, Gender Bias or Discrimination Training, ADVANCE STRIDE trainer
Research Interests:

Virology, pathogenesis