virus-cell interaction, positive-strand RNA viruses, flaviviruses, cell biology of RNA virus infeciton
G protein coupled receptors (GPCRs) activate heterotrimeric G proteins to control myriad signaling pathways and physiological processes. Our lab broadly studies these signaling circuits with current emphasis on delineating the function of adhesion GPCRs and Ric-8 proteins (folding chaperones for all G protein alpha subunits). Adhesion GPCRs appear to couple extracellular shear force events to intracellular G protein signaling. We use a wide range of approaches, including purified protein structure/function, cell culture models, GPCR drug screening, and transgenic animal models.
Nucleotide Repeat expansions; protein translation; neurodegeneration; RNA biology; ALS/FTD; Ataxia.
Our laboratory is interested in elucidating the molecular mechanisms underlying chromatin modifications that regulate gene expression and other chromatin-associated functions. Our studies are primarily focused on the enzymes that dynamically control the methylation status of lysines in histones and non-histone proteins using structural and biochemical approaches.
The Truttmann laboratory studies molecular chaperone functions in the context of proteostasis, aging and aging-associated diseases (e.g. Alzheimer’s disease, Huntington’s disease, Ataxias, etc.). We are particularly interested in the regulation and functions of heat shock protein 70 (Hsp70) family proteins (e.g. HSC70, Grp78/BiP, etc.). We employ numerous genetic, biochemical as well as behavioral approaches in conjunction with several model systems (tissue culture, Caenorhabditis elegans, mice, primary human tissue) to address our research questions in a holistic fashion.
Aging and stress response pathways