The mechanisms of myelin targeting in the inner ear.
The Walter group studies the cellular and molecular biology of ubiquitous non-coding RNAs, composing perhaps 90% of the human genome and broadly responsible for the regulation of gene expression, by mechanistic single molecule and super-resolution fluorescence microscopy tools inside and outside of live cells. Applications of this leading-edge, highly interdisciplinary work include the identification and optimization of novel RNA-targeting drugs for gene therapy and of RNA and DNA as diagnostic biomarkers.
Golgi biogenesis, function, and defects in diseases
Heart regeneration using a combination of stem cells, small molecules, bioengineering, and large animal models.
We seek to understand essential cellular processes — using cultured neurons, cell lines and yeast — in order to shed new light on neurodegeneration, cancer and other diseases.
Normal as well as neoplastic cell populations remodel the extracellular matrix by regulating the expression of complex gene programs that control cell motility, proteolytic activity, proliferation and morphogenesis. However, the identity of the upstream and downstream gene products that regulate these activities in normal or pathologic states remain unclear, especially within the context of the 3-dimensional matrix. Current efforts focus on identifying the regulation of transcription factors that control epithelial-mesenchymal transitions in carcinomatous states as well as the genetic...
Our lab profiles the mechanisms by which multi-nucleated osteoclasts stimulate osteoblastic bone formation in order to identify novel therapeutic targets to promote bone formation in aging and cancer-induced bone disease. We use cell culture and animal models to dissect out osteo-immunology signaling pathways differentially regulated in osteoclast resorption and stimulation of bone formation. We are working across disciplines (engineering, materials science, pharmacy, medicine) to develop novel tools to study resorption and single cell osteoclast dynamics.
Cardiac myocyte; Sarcomere; Post-translational Modifications; Protein kinase C
meiosis, protein structure
DNA repair, mutagenesis, transcription, genomics, bioinformatics
virus-host interactions in the intestine, norovirus, astrovirus, human intestinal organoids
cancer biology, stem cell biology, skin, epithelial tissue
Mechanism of neurodegeneration in Amyotrophic Lateral Sclerosis (ALS)
diabetes, obesity, thermogenic fat, alcoholic liver disease