People

(Includes Name, Title, Research Interests)
Pediatrics and Communicable Diseases, Division of Neonatal-Perinatal Medicine
Research Interests:

Our lab concentrates on the molecular characterization of common and rare variants in genes associated with bleeding or thrombosis risk in humans. Through the study of large cohorts of human subjects, we and others have identified genetic variants associated with altered risk for disease. In our lab, we employ molecular and cellular techniques, such as mammalian cell culture, proteomic profiling, genome-wide CRISPR mediated knock-out screens, and mutagenesis libraries to functionally characterize the altered molecular genetic mechanisms contributing to disease risk.

Poth Professor of Cutaneous Oncology
Professor, Departments of Dermatology and Cell & Developmental Biology
Accepting New Students:
No
Research Interests:

Hedgehog-driven cancers, viral oncogenesis, non-melanoma skin cancers

Collegiate Professor of Pathology Research
Accepting new students?
No
Research Interests:

Developmental biology, stem cells, epigenetics, kidney disease

Mark Dulchavsky Headshot
MSTP Student
Mentor:
James Bardwell
Joined CMB:
2019
Undergraduate Institution:
University of Michigan
Research Interests:

Protein therapeutics - evolution, delivery, and design

Associate Director, Cell & Developmental Biology
Accepting new students?
Yes
DEI Statement:
I am the director for Diversity Equity and Inclusion for my home department, a member of the inclusive admissions working group, and a Rackham faculty Ally for Diversity. In these roles and in my own lab, I focus on equity and inclusion because I feel that supporting our current trainees is the best way serve the needs of UM and society.
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Allyship Training, Bystander Training
Research Interests:

Membrane traffic, Cell polarity, Protein interactions, Yeast, Organoids

Mentor:
Mentor: Dr. Megan Weivoda, Co-Mentor: Dr. Evan Keller
Joined CMB:
2020
Undergraduate Institution:
Loras College - Dubuque, IA
Honors:
ECTS and ASBMR Young Investigator Award, Ed Cawley Undergraduate Research Thesis Scholarship Recipient
Service:
PIBS interview weekend host, 'Matchathon' orientation event organizer
Research Interests:

Osteoimmunology

Assistant Professor of Molecular, Cellular, and Developmental Biology
Accepting new students?
Yes
DEI Statement:
My long-term goal is to make STEM education at the undergraduate and graduate levels more inclusive and equitable so that it is welcoming to individuals from different identities and backgrounds. In 2020-2021 I was the Rackham Faculty mentor for Diversity and the MCDB DEI Officer and chair of the DEI committee. I also organize the NextProf workshop for our department and I am a HHMI Gilliam Fellowship mentor, and the founder and faculty advisor of FIRST, Future in Research, Science, and Teaching, the first pre-science undergraduate club on campus. FIRST engages students in the life sciences to demystify the process of becoming a scientist, supports their academic growth, and prepares and guides them through summer research and PhD applications. At the graduate level, I have lectured and participated in several panels on how to become involved in science communication and increase participation in the process of science.
Trainings and Identities:
Implicit Bias Training, Anti-Racism Training, Intergroup Relations (IGR - through OHEI), Intercultural Training, Bystander Training, Rackham Faculty Ally, Gilliam HHMI Mentor, Immigrant-Identified
Research Interests:

Nutriepigenetics, metabolism, processed food, feeding behavior

Mentor:
Michael Cianfrocco
Joined CMB:
2019
Undergraduate Institution:
Mississippi State University & University of Wisconsin at Madison
Service:
Science Saturdays coordinator for community outreach in Madison, WI 2017-2018; DNA Day 2019
Research Interests:

The use of cryo-electron microscopy to study the mitochondrial membrane protein, Miro.

Internal Medicine
Research Interests:

Our lab focuses on the genetic determinants of thrombosis, atherosclerosis, and inflammation.

Dermatology/Radiation Oncology
Research Interests:

Our laboratory is interested in molecular mechanisms controlling epidermal growth and differentiation, including how this process is linked to host defense and autoimmunity. For this purpose, we utilize cell biology, organ culture, transgenic animals, genetic linkage analysis, and gene expression profiling.

Najia Elkahlah
Joined CMB:
2021
Mentor:
Dr. Josie Clowney
Research Interests:

Understanding the genetic mechanisms regulating the development and function of neural circuits controlling innate behaviors

Understanding the genetic mechanisms regulating the
development and function of neural circuits controlling innate behaviors.

 

Carina Elvira
Joined CMB:
2021
Mentor:
Dr. Paul Jenkins
Undergraduate Institution:
University of Chicago
Research Interests:

Role of Ankyrins in neuropsychiatric disorders, such as bipolar disorder and autism spectrum disorder. 

Mentor:
Jordan Shavit
Joined CMB:
2019
Undergraduate Institution:
University of South Florida
Service:
AWIS, Forsythe Middle School Student Mentor, Patient Companionship, Caregiver Relief and Pet Visit Volunteer (Hospice), Road to Recovery Driver (American Cancer Society), Oyster Gardner (Restore the Shore, Brevard County FL)
Honors:
Excellence in Undergraduate Research Award
Neurosurgery/Cell and Developmental Biology
Research Interests:
Develop novel therapies for the malignant brain tumors based on depletion of cancer stem like cells.

 

Internal Medicine/Human Genetics
Research Interests:

Cancer genetics, gastrointestinal cancer, oncogenes, tumor suppressor genes, beta-catenin, Wnt signaling, developmental biology, CDX2, E-cadherin.

Neurology
Research Interests:

The role of growth factors in the pathogenesis and treatment of neurologic disorders.

Pathology
Research Interests:
DNA Repair and Genomic Stability in Mammals. We study how DNA repair prevents cancer, controls development of the immune system, and ensures proper overall mammalian development.

 

Cell and Developmental Biology
Research Interests:

Regulation of signal transduction by the conserved protein kinase mTOR, the mammalian target of rapamycin.

Jacqueline Forson
Joined CMB:
2021
Mentor:
Dr. Ryan Baldridge
Research Interests:

Protein Quality Control 

Patrice Fort
Associate Professor of Ophthalmology and Visual Sciences, Director of the Vision Research Training Program (NEI-T32) of the UM Kellogg Eye Center
Accepting new students?
Yes
DEI Statement:
Our laboratory fosters collaboration, communication, and involvement of each lab members without distinctions relative to level of training or origin. It is the expectation that everyone participates in the lab's life to the extent they can and it is recognized that everyone has a different perspective that adds value to the discussion. Through my role in recruitment committees and course and training program director, I am particularly sensitive to the philosophy of holistic review process.
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training
Research Interests:

Intrinsic retinal neuron survival mechanisms; retinal glial cells implications in pathological and normal retinal functions; crystallin protein functions in the retina; signaling pathways regulation; regulation of the retinal inflammatory response

Marcus L. Ward Collegiate Professor of Dentistry (Periodontics & Oral Medicine)
Accepting New Students?
No
Research Interests:
Skeletal development, role of collagen-cell signaling in craniofacial development 
Associate Professor of Biological Chemistry
Accepting new students?
Yes
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, CMB DEI Month Book Club, Bystander Training
Research Interests:

Systems biology, transcription, regulatory networks, microbiology, genome structure

Ophthalmology and Visual Sciences
Research Interests:

The goal of our laboratory is to understand the molecular mechanisms underlying normal and abnormal mammalian eye development. The approaches we employ include mouse models, functional genomics, and cell culture systems.

Santhi Ganesh
Associate Professor of Internal Medicine
Accepting new students?
Yes
DEI Statement:
Our lab values curiosity, honesty, respect, open-mindedness, and communication. Diversity is an asset to the lab and allows us to benefit from the unique experiences of all group members. We strive to ensure equitable access to resources and opportunities in the lab, and to make the lab a welcoming environment for all.
Trainings and Identities:
Implicit Bias Training
Research Interests:

Genetics, genomics, smooth muscle cells, vascular diseases, translational science

Elizabeth Gensterblum-Miller
Mentor:
Chad Benner
Joined CMB:
2018
Undergraduate Institution
Michigan State University
Assistant Professor of Biomedical Engineering, Affiliate Faculty in Biological Chemistry
Accepting new students?
Yes
Research Interests:

Encapsulins, Protein Nanocompartments, cryo-EM, Microbiology, Synthetic Biology

Cell and Developmental Biology
Research Interests:

A long standing goal of our research is to understand how neuronal growth and sprouting is regulated in the mammalian nervous system during development, adult neuronal plasticity, and following injury (i.e. spinal cord injury, traumatic brain injury, stroke or multiple sclerosis). We pursue a mouse genetic approach to study the function of different classes of proteins that are known to regulate neuronal growth, including members of the Semaphorin family and their cognate receptors (Neuropilins and Plexins), myelin-associated inhibitors and their receptors. The Nogo Receptors NgR1 and NgR2...

Mentor:
Scott Soleimanpour
Joined CMB:
2017
Undergraduate Institution:
Western Washington University Honors College
Service:
Ann Arbor Hands-On Museum, Michigan Health Sciences Pre Exposure Academy, UROP mentoring
Research Interests:
I work in a beta-cell biology and diabetes lab. We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.
Research Interests:

I work in a beta-cell biology and diabetes lab.  We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.

David Ginsburg
James V. Neel Distinguished University Professor Departments of Internal Medicine, Human Genetics, and Pediatrics Howard Hughes Medical Institute and Life Sciences Institute
Accepting new students?
Possibly
Research Interests:

Thrombosis, hemostasis, endothelial cells, protein engineering, ER-Golgi trafficking.

Human Genetics/Pediatrics
Research Interests:

Molecular cytogenetics and the molecular biology of human disease.

Professor of Neuroscience and Biological Chemistry, Michigan Neuroscience Institute
Accepting new students?
Yes
Trainings and Identitites:
Implicit Bias Training, Anti-Racism Training, Bystander Training, Gender Bias or Discrimination Training
Research Interests:

stem cells, retina, central nervous system, regeneration

INTERNAL MEDICINE/GERONTOLOGY/CARDIOVASCULAR AGING
Research Interests:

The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging

MSTP Student
Mentor:
Sami Barmada, M.D., Ph.D.
Joined CMB:
2017
Undergraduate Institution:
Tufts University
Mentor:
Alice Telesnitsky
Undergraduate Institution
University of Wisconsin - Madison
Service
AWIS
Joined CMB:
2019
Research Interests:

Structural dynamics of HIV-1 RNA

Desiree Gordian
Joined CMB:
2021
Mentor:
Dr. Martin Myers
Research Interests:

Diabetes metabolism, and neuronal circuits

James Haggerty-Skeans
MSTP Student
Mentor:
Sriram Venneti, M.D., Ph.D.
Joined CMB:
2020
Undergraduate Institution:
UCLA
Research Interests:

Our lab studies how epigenetic and metabolic dysregulation influence the development and biology of pediatric brain tumors. My work focuses on a novel epigenetic modifier, EZHIP, which is overexpressed in a subtype of childhood brain cancer known as PF-A ependymomas. EZHIP inhibits polycomb-mediated trimethylation at histone H3 lysine 27 (H3K27me3), a transcriptionally repressive chromatin modifying mark. EZHIP overexpression gives rise to a global reduction in H3K27me3 marks throughout the genome that is poorly prognostic. My project aims to understand the mechanisms regulating EZHIP...

Maha Hamed
Joined CMB:
2020
Mentor:
Dr. Mara Duncan
Undergraduate Institution:
University of Missouri
Honors:
Rackham Merit Fellowship (2019), NIH IMSD EXPRESS Fellowship (2016-2019)
Service:
FEMMES, Wolverine Pathways
Research Interests:

Investigating the role of membrane trafficking in development

Gary Hammer
Millie Schembechler Professor of Adrenal Cancer, Director of the Endocrine Oncology Program, Professor of Internal Medicine
Accepting new students?
Yes
DEI Statement:
In the clinic, the lab and classroom - all are valued, welcomed, respected and desired equally - independent of the often historic hierarchical nature of medical and graduate training.
Trainings and Identities:
Clinician and scientist (basic, translational and clinical research), academic and industry engagement
Research Interests:

adrenal homeostasis and disease

Assistant Professor of Human Genetics and Assistant Professor of Obstetrics and Gynecology
Minor J. Coon Collegiate Professor, Biological Chemistry Chair, Biological Chemistry
Research Interests:

Work in the Hanson lab addresses fundamental questions about how cells regulate the structure
and organization of their membranes. We use biochemical, cellular, and imaging approaches to
study molecular reactions that control trafficking and organelle function with a particular interest
in how the ESCRT machinery acts to remodel and repair membranes. Available projects are
relevant to understanding the pathophysiology of neurodegenerative disorders, infectious
disease, cancer and more.

Mara Harwood
Joined CMB:
2018
Mentor:
Dr. Billy Tsai
Undergraduate Institutions:
Grays Harbor College and Mills College
Research Interests:

Intracellular Trafficking Mechanisms of Human Papillomavirus (HPV)

Assistant Professor of Cell and Developmental Biology
Accepting new students?
Yes
DEI Statement:
I strive to create an environment where everyone can reach their full potential and be their true self.
Trainings and Identities:
MORE Mentor Training, Operation Opportunity
Research Interests:

stem cells, development, quantitative and systems biology

MSTP Student
Mentor:
Eva Feldman
Joined CMB:
2018
Mentor:
Scott Pletcher, Ph.D.
Joined CMB:
2020
Pharmacology
Research Interests:
Our lab is interested in understanding the mechanisms by which oxidized lipids regulate platelet activation, hemostasis, and thrombosis in physiological conditions as well as pathophysiological conditions such as cardiovascular disease and diabetes. Additionally, our lab is interested in understanding the underlying differences in inherent platelet function by race at a genetic, protein, and whole animal level. Our studies involve studying platelet function from human subjects, animals, as well as cell and molecular level analyses.

 

Professor of Internal Medicine
Accepting new students?
Yes
DEI Statement:
Our laboratory is fully committed to DEI. Over my 32 years at UM, I have had a highly diverse group of employees, students and postdoctoral trainees representing 25 different countries of all ethnic groups and religious affiliations.
Research Interests:

Autoimmune diseases, Signal transduction, Mechanisms of MHC-disease association, Transcriptomics, Drug development

Marshall Howington
Mentor:
Scott Leiser
Joined CMB:
2018
Undergraduate Institution:
University of North Carolina
Research Interests:

Aging, biogerontology, stress resistance, longevity

MSTP Student
Mentor:
Benjamin Levi, MD
Joined CMB:
2019
Undergraduate Institution:
Duke University
Research Interests:

Heterotopic ossification, lymphatic development, tendon repair

Michael Imperiale
Arthur F. Thurnau Professor of Microbiology and Immunology
Accepting new students?
No
DEI Statement:
Each member of our lab team has unique, valued contributions to make.
Trainings and Identities:
Implicit Bias Training, Anti-Racism Training, Bystander Training, First Generation-Identified
Research Interests:

Virology, Viral Genetics, Virus-Host Cell Interactions

Associate Professor of Molecular and Integrative Physiology, and Life Sciences Institute
Accepting new students?
Yes
Trainings and Identities:
Anti-Racism Training, Intercultural Training
Research Interests:

mTOR, cancer, metabolic disorders, diabetes, diabetic kidney disease

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