Our lab concentrates on the molecular characterization of common and rare variants in genes associated with bleeding or thrombosis risk in humans. Through the study of large cohorts of human subjects, we and others have identified genetic variants associated with altered risk for disease. In our lab, we employ molecular and cellular techniques, such as mammalian cell culture, proteomic profiling, genome-wide CRISPR mediated knock-out screens, and mutagenesis libraries to functionally characterize the altered molecular genetic mechanisms contributing to disease risk.
The Dressler lab utilizes genetic and biochemical approaches to understand the development of the kidney and reproductive tract. The lab has identified multiple epigenetic and cell signaling pathways that control epithelial cell lineage specification and differentiation. These pathways also contribute to chronic and acute renal disease and cancer, for which novel therapeutics are being developed.
Membrane traffic, Cell polarity, Protein interactions, Yeast, Organoids
The use of cryo-electron microscopy to study the mitochondrial membrane protein, Miro.
Our laboratory is interested in molecular mechanisms controlling epidermal growth and differentiation, including how this process is linked to host defense and autoimmunity. For this purpose, we utilize cell biology, organ culture, transgenic animals, genetic linkage analysis, and gene expression profiling.
Understanding the genetic mechanisms regulating the development and function of neural circuits controlling innate behaviors
Understanding the genetic mechanisms regulating the
development and function of neural circuits controlling innate behaviors.
Role of Ankyrins in neuropsychiatric disorders, such as bipolar disorder and autism spectrum disorder.
Protein Quality Control
Our research focuses on studying retinal diseases and their mechanisms, in order to develop new treatments to prevent or reverse associated vision loss. A major focus in our lab is the development of strategies to treat retinal neurodegenerations, including diabetic retinopathy. One of our objectives is to investigate the function and regulation of crystallin proteins in the adaptive responses of retinal cells during chronic disease states such as diabetes.
Systems biology, transcription, regulatory networks, microbiology, genome structure
The goal of our laboratory is to understand the molecular mechanisms underlying normal and abnormal mammalian eye development. The approaches we employ include mouse models, functional genomics, and cell culture systems.
Genetics, genomics, smooth muscle cells, vascular diseases, translational science
We are interested in the chemistry, biology and molecular engineering of microbes. The current focus lies on understanding and engineering megadalton protein organelles involved in stress resistance, nutrient utilization and pathogenicity and on the discovery and characterization of novel enzymatic transformations and bioactive compounds. Based on our fundamental discoveries regarding bacterial metabolism and cell biology, we utilize protein and metabolic engineering to create the next generation of living diagnostics and therapeutics, programmable nanomaterials and nanoreactors. Our...
A long standing goal of our research is to understand how neuronal growth and sprouting is regulated in the mammalian nervous system during development, adult neuronal plasticity, and following injury (i.e. spinal cord injury, traumatic brain injury, stroke or multiple sclerosis). We pursue a mouse genetic approach to study the function of different classes of proteins that are known to regulate neuronal growth, including members of the Semaphorin family and their cognate receptors (Neuropilins and Plexins), myelin-associated inhibitors and their receptors. The Nogo Receptors NgR1 and NgR2...
I work in a beta-cell biology and diabetes lab. We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.
Thrombosis, hemostasis, endothelial cells, protein engineering, ER-Golgi trafficking.
We investigate the cellular and molecular mechanisms underlying retina regeneration in zebrafish and neuromuscular synapse regeneration in mice. We anticipate this research will suggest novel strategies for stimulating retinal repair in people suffering from blinding eye diseases and enhance motor function in people suffering from motor neuron disease and age-related sarcopenia.
The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging
Our lab studies how epigenetic and metabolic dysregulation influence the development and biology of pediatric brain tumors. My work focuses on a novel epigenetic modifier, EZHIP, which is overexpressed in a subtype of childhood brain cancer known as PF-A ependymomas. EZHIP inhibits polycomb-mediated trimethylation at histone H3 lysine 27 (H3K27me3), a transcriptionally repressive chromatin modifying mark. EZHIP overexpression gives rise to a global reduction in H3K27me3 marks throughout the genome that is poorly prognostic. My project aims to understand the mechanisms regulating EZHIP...
Investigating the role of membrane trafficking in development
Dr. Gary D. Hammer, M.D., Ph.D. is a medical endocrinologist specializing in the treatment of adrenal and gonadal diseases. Work in his laboratory has focused on the mechanisms by which signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on the dysregulated growth of adrenocortical stem cells in development and cancer.
Work in the Hanson lab addresses fundamental questions about how cells regulate the structure
and organization of their membranes. We use biochemical, cellular, and imaging approaches to
study molecular reactions that control trafficking and organelle function with a particular interest
in how the ESCRT machinery acts to remodel and repair membranes. Available projects are
relevant to understanding the pathophysiology of neurodegenerative disorders, infectious
disease, cancer and more.
Our goal is to understand how human pluripotent stem cells generate and interpret the chemical and physical signals that allow them to self-organize into spatial structures consisting of multiple cell types in vitro, and, by extension to the embryo, in vivo. By combining quantitative live-cell measurements and engineering tools such as micropatterning with predictive mathematical models we can answer currently intractable questions in developmental and stem cell biology.
Our laboratory studies the molecular biology of the small DNA tumor virus, BK polyomavirus. BKPyV is a ubiquitous human pathogen that establishes a subclinical, persistent infection of the urinary tract during early childhood. In healthy individuals, the virus is excreted periodically into the urine but does not cause disease, but in renal and bone marrow transplant patients, the virus can cause severe and sometimes life threatening illnesses. We are interested in the interplay between viral and host factors that determine whether the virus will persist or replicate in the cell. On the...
Our laboratory investigates the function and regulation of nutrient/energy-sensing molecules such as mTOR and AMP kinase in the development of human diseases including cancer and metabolic disorders such as diabetic complications.