People

(Includes Name, Title, Research Interests)
Pediatrics and Communicable Diseases, Division of Neonatal-Perinatal Medicine
Research Interests:

Our lab concentrates on the molecular characterization of common and rare variants in genes associated with bleeding or thrombosis risk in humans. Through the study of large cohorts of human subjects, we and others have identified genetic variants associated with altered risk for disease. In our lab, we employ molecular and cellular techniques, such as mammalian cell culture, proteomic profiling, genome-wide CRISPR mediated knock-out screens, and mutagenesis libraries to functionally characterize the altered molecular genetic mechanisms contributing to disease risk.

Poth Professor of Cutaneous Oncology
Professor, Departments of Dermatology and Cell & Developmental Biology
Accepting New Students:
No
Research Interests:

Hedgehog-driven cancers, viral oncogenesis, non-melanoma skin cancers

Pathology
Research Interests:

The Dressler lab utilizes genetic and biochemical approaches to understand the development of the kidney and reproductive tract. The lab has identified multiple epigenetic and cell signaling pathways that control epithelial cell lineage specification and differentiation. These pathways also contribute to chronic and acute renal disease and cancer, for which novel therapeutics are being developed.  

Mark Dulchavsky Headshot
MSTP Student
Mentor:
James Bardwell
Year in CMB:
2019
Undergraduate Institution:
University of Michigan
Research Interests:

Protein therapeutics - evolution, delivery, and design

Associate Director, Cell & Developmental Biology
Accepting new students?
Yes
DEI Statement:
I am the director for Diversity Equity and Inclusion for my home department, a member of the inclusive admissions working group, and a Rackham faculty Ally for Diversity. In these roles and in my own lab, I focus on equity and inclusion because I feel that supporting our current trainees is the best way serve the needs of UM and society.
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Allyship Training, Bystander Training
Research Interests:

Membrane traffic, Cell polarity, Protein interactions, Yeast, Organoids

Mentor:
Mentor: Dr. Megan Weivoda, Co-Mentor: Dr. Evan Keller
Year:
2019
Undergraduate Institution:
Loras College - Dubuque, IA
Honors:
ECTS and ASBMR Young Investigator Award, Ed Cawley Undergraduate Research Thesis Scholarship Recipient
Service:
PIBS interview weekend host, 'Matchathon' orientation event organizer
Research Interests:

Osteoimmunology

Molecular, Cellular, and Developmental Biology
Research Interests:
The goal of the lab is to understand the molecular and neural mechanisms behind behavior and to reflect on the role of the environment on the functioning of neural circuits. Our lab uses both molecular ("omics", genetics, etc.) and neurobiology techniques, such as behavior and in vivo brain imaging. Our goal is to uncover the molecular events underlying the establishment of behavioral states. A main focus of the lab is to study how neurons sense nutrients and how this impacts feeding behavior.

 

Mentor:
Michael Cianfrocco
Year:
2018
Undergraduate Institution:
Mississippi State University & University of Wisconsin at Madison
Service:
Science Saturdays coordinator for community outreach in Madison, WI 2017-2018; DNA Day 2019
Research Interests:

The use of cryo-electron microscopy to study the mitochondrial membrane protein, Miro.

Internal Medicine
Research Interests:

Our lab focuses on the genetic determinants of thrombosis, atherosclerosis, and inflammation.

Dermatology/Radiation Oncology
Research Interests:

Our laboratory is interested in molecular mechanisms controlling epidermal growth and differentiation, including how this process is linked to host defense and autoimmunity. For this purpose, we utilize cell biology, organ culture, transgenic animals, genetic linkage analysis, and gene expression profiling.

Najia Elkahlah
Joined CMB:
2021
Mentor:
Dr. Josie Clowney
Research Interests:

Understanding the genetic mechanisms regulating the development and function of neural circuits controlling innate behaviors

Understanding the genetic mechanisms regulating the
development and function of neural circuits controlling innate behaviors.

 

Carina Elvira
Joined CMB:
2021
Mentor:
Dr. Paul Jenkins
Undergraduate Institution:
University of Chicago
Research Interests:

Role of Ankyrins in neuropsychiatric disorders, such as bipolar disorder and autism spectrum disorder. 

Mentor:
Jordan Shavit
Year:
2018
Undergraduate Institution:
University of South Florida
Service:
AWIS, Forsythe Middle School Student Mentor, Patient Companionship, Caregiver Relief and Pet Visit Volunteer (Hospice), Road to Recovery Driver (American Cancer Society), Oyster Gardner (Restore the Shore, Brevard County FL)
Honors:
Excellence in Undergraduate Research Award
Neurosurgery/Cell and Developmental Biology
Research Interests:
Develop novel therapies for the malignant brain tumors based on depletion of cancer stem like cells.

 

Internal Medicine/Human Genetics
Research Interests:

Cancer genetics, gastrointestinal cancer, oncogenes, tumor suppressor genes, beta-catenin, Wnt signaling, developmental biology, CDX2, E-cadherin.

Neurology
Research Interests:

The role of growth factors in the pathogenesis and treatment of neurologic disorders.

Pathology
Research Interests:
DNA Repair and Genomic Stability in Mammals. We study how DNA repair prevents cancer, controls development of the immune system, and ensures proper overall mammalian development.

 

Cell and Developmental Biology
Research Interests:

Regulation of signal transduction by the conserved protein kinase mTOR, the mammalian target of rapamycin.

Jacqueline Forson
Joined CMB:
2021
Mentor:
Dr. Ryan Baldridge
Research Interests:

Protein Quality Control 

Cell and systems biology; Genetics/gene regulation, genomics/proteomics, computational biology; Molecular mechanisms of disease, cancer biology
Research Interests:

Our research focuses on studying retinal diseases and their mechanisms, in order to develop new treatments to prevent or reverse associated vision loss. A major focus in our lab is the development of strategies to treat retinal neurodegenerations, including diabetic retinopathy. One of our objectives is to investigate the function and regulation of crystallin proteins in the adaptive responses of retinal cells during chronic disease states such as diabetes.

Marcus L. Ward Collegiate Professor of Dentistry (Periodontics & Oral Medicine)
Accepting New Students?
No
Research Interests:
Skeletal development, role of collagen-cell signaling in craniofacial development 
Associate Professor of Biological Chemistry
Accepting new students?
Yes
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, CMB DEI Month Book Club, Bystander Training
Research Interests:

Systems biology, transcription, regulatory networks, microbiology, genome structure

Ophthalmology and Visual Sciences
Research Interests:

The goal of our laboratory is to understand the molecular mechanisms underlying normal and abnormal mammalian eye development. The approaches we employ include mouse models, functional genomics, and cell culture systems.

Santhi Ganesh
Associate Professor of Internal Medicine
Accepting new students?
Yes
DEI Statement:
Our lab values curiosity, honesty, respect, open-mindedness, and communication. Diversity is an asset to the lab and allows us to benefit from the unique experiences of all group members. We strive to ensure equitable access to resources and opportunities in the lab, and to make the lab a welcoming environment for all.
Trainings and Identities:
Implicit Bias Training
Research Interests:

Genetics, genomics, smooth muscle cells, vascular diseases, translational science

Elizabeth Gensterblum-Miller
Mentor:
Chad Benner
Year:
2017
Undergraduate Institution
Michigan State University
Biomedical Engineering
Research Interests:

We are interested in the chemistry, biology and molecular engineering of microbes. The current focus lies on understanding and engineering megadalton protein organelles involved in stress resistance, nutrient utilization and pathogenicity and on the discovery and characterization of novel enzymatic transformations and bioactive compounds. Based on our fundamental discoveries regarding bacterial metabolism and cell biology, we utilize protein and metabolic engineering to create the next generation of living diagnostics and therapeutics, programmable nanomaterials and nanoreactors. Our...

Cell and Developmental Biology
Research Interests:

A long standing goal of our research is to understand how neuronal growth and sprouting is regulated in the mammalian nervous system during development, adult neuronal plasticity, and following injury (i.e. spinal cord injury, traumatic brain injury, stroke or multiple sclerosis). We pursue a mouse genetic approach to study the function of different classes of proteins that are known to regulate neuronal growth, including members of the Semaphorin family and their cognate receptors (Neuropilins and Plexins), myelin-associated inhibitors and their receptors. The Nogo Receptors NgR1 and NgR2...

Mentor:
Scott Soleimanpour
Year:
2016
Undergraduate Institution:
Western Washington University Honors College
Service:
Ann Arbor Hands-On Museum, Michigan Health Sciences Pre Exposure Academy, UROP mentoring
Research Interests:
I work in a beta-cell biology and diabetes lab. We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.
Research Interests:

I work in a beta-cell biology and diabetes lab.  We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.

David Ginsburg
James V. Neel Distinguished University Professor Departments of Internal Medicine, Human Genetics, and Pediatrics Howard Hughes Medical Institute and Life Sciences Institute
Accepting new students?
Possibly
Research Interests:

Thrombosis, hemostasis, endothelial cells, protein engineering, ER-Golgi trafficking.

Human Genetics/Pediatrics
Research Interests:

Molecular cytogenetics and the molecular biology of human disease.

Biological Chemistry
Research Interests:

We investigate the cellular and molecular mechanisms underlying retina regeneration in zebrafish and neuromuscular synapse regeneration in mice. We anticipate this research will suggest novel strategies for stimulating retinal repair in people suffering from blinding eye diseases and enhance motor function in people suffering from motor neuron disease and age-related sarcopenia.

INTERNAL MEDICINE/GERONTOLOGY/CARDIOVASCULAR AGING
Research Interests:

The overall theme of Dr. Goldstein’s laboratory is how inflammation impacts different disease states. Broadly, Dr. Goldstein’s laboratory investigates the importance of inflammation in organ transplantation, and in aging

MSTP Student
Mentor:
Sami Barmada, M.D., Ph.D.
Year:
2016
Undergraduate Institution:
Tufts University
Mentor:
Alice Telesnitsky
Undergraduate Institution
University of Wisconsin - Madison
Service
AWIS
Research Interests:

Structural dynamics of HIV-1 RNA

Desiree Gordian
Joined CMB:
2021
Mentor:
Dr. Martin Myers
Research Interests:

Diabetes metabolism, and neuronal circuits

James Haggerty-Skeans
MSTP Student
Mentor:
Sriram Venneti, M.D., Ph.D.
Undergraduate Institution:
UCLA
Research Interests:

Our lab studies how epigenetic and metabolic dysregulation influence the development and biology of pediatric brain tumors. My work focuses on a novel epigenetic modifier, EZHIP, which is overexpressed in a subtype of childhood brain cancer known as PF-A ependymomas. EZHIP inhibits polycomb-mediated trimethylation at histone H3 lysine 27 (H3K27me3), a transcriptionally repressive chromatin modifying mark. EZHIP overexpression gives rise to a global reduction in H3K27me3 marks throughout the genome that is poorly prognostic. My project aims to understand the mechanisms regulating EZHIP...

Maha Hamed
Joined CMB:
2020
Mentor:
Dr. Mara Duncan
Undergraduate Institution:
University of Missouri
Honors:
Rackham Merit Fellowship (2019), NIH IMSD EXPRESS Fellowship (2016-2019)
Service:
FEMMES, Wolverine Pathways
Research Interests:

Investigating the role of membrane trafficking in development

Internal Medicine/Mol. Integ. Physiol
Research Interests:

Dr. Gary D. Hammer, M.D., Ph.D. is a medical endocrinologist specializing in the treatment of adrenal and gonadal diseases. Work in his laboratory has focused on the mechanisms by which signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on the dysregulated growth of adrenocortical stem cells in development and cancer.

Assistant Professor of Human Genetics and Assistant Professor of Obstetrics and Gynecology
Minor J. Coon Collegiate Professor, Biological Chemistry Chair, Biological Chemistry
Research Interests:

Work in the Hanson lab addresses fundamental questions about how cells regulate the structure
and organization of their membranes. We use biochemical, cellular, and imaging approaches to
study molecular reactions that control trafficking and organelle function with a particular interest
in how the ESCRT machinery acts to remodel and repair membranes. Available projects are
relevant to understanding the pathophysiology of neurodegenerative disorders, infectious
disease, cancer and more.

Mara Harwood
Joined CMB:
2018
Mentor:
Dr. Billy Tsai
Undergraduate Institutions:
Grays Harbor College and Mills College
Research Interests:

Intracellular Trafficking Mechanisms of Human Papillomavirus (HPV)

Cell & Developmental Biology
Research Interests:

Our goal is to understand how human pluripotent stem cells generate and interpret the chemical and physical signals that allow them to self-organize into spatial structures consisting of multiple cell types in vitro, and, by extension to the embryo, in vivo. By combining quantitative live-cell measurements and engineering tools such as micropatterning with predictive mathematical models we can answer currently intractable questions in developmental and stem cell biology.

MSTP Student
Mentor:
Eva Feldman
Year:
2017
Mentor:
Scott Pletcher, Ph.D.
Pharmacology
Research Interests:
Our lab is interested in understanding the mechanisms by which oxidized lipids regulate platelet activation, hemostasis, and thrombosis in physiological conditions as well as pathophysiological conditions such as cardiovascular disease and diabetes. Additionally, our lab is interested in understanding the underlying differences in inherent platelet function by race at a genetic, protein, and whole animal level. Our studies involve studying platelet function from human subjects, animals, as well as cell and molecular level analyses.

 

Internal Medicine
Research Interests:
The role of signal transduction events in health and disease.

 

Marshall Howington
Mentor:
Scott Leiser
Year:
2017
Undergraduate Institution:
University of North Carolina
Research Interests:

Aging, biogerontology, stress resistance, longevity

MSTP Student
Mentor:
Benjamin Levi, MD
Year in CMB:
2019
Undergraduate Institution:
Duke University
Research Interests:

Heterotopic ossification, lymphatic development, tendon repair

Michael Imperiale
Microbiology and Immunology
Research Interests:

Our laboratory studies the molecular biology of the small DNA tumor virus, BK polyomavirus. BKPyV is a ubiquitous human pathogen that establishes a subclinical, persistent infection of the urinary tract during early childhood. In healthy individuals, the virus is excreted periodically into the urine but does not cause disease, but in renal and bone marrow transplant patients, the virus can cause severe and sometimes life threatening illnesses. We are interested in the interplay between viral and host factors that determine whether the virus will persist or replicate in the cell. On the...

Molecular and Integrative Physiology and the Internal Medicine
Research Interests:

Our laboratory investigates the function and regulation of nutrient/energy-sensing molecules such as mTOR and AMP kinase in the development of human diseases including cancer and metabolic disorders such as diabetic complications.

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