People

(Includes Name, Title, Research Interests)
Lori Isom
Maurice H. Seevers Professor and Chair of Pharmacology
Accepting new students?
MORE Mentor Training, Implicit Bias Training, Allyship Training, Anti-Racism Training, Change It Up!, Disability Awareness Training, Bystander Training, Gender Bias or Discrimination Training
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Allyship Training, Anti-Racism Training, Change It Up!, Disability Awareness Training, Bystander Training, Gender Bias or Discrimination Training
Research Interests:

We study the mechanisms of pediatric epileptic encephalopathy, sudden unexpected death in epilepsy (SUDEP), and cardiac arrhythmia linked to mutations in voltage-gated sodium channel genes. Experimental models in our lab include transgenic mouse lines and human patient-derived induced pluripotent stem cell neurons and cardiac myocytes.

Molecular Cellular and Development Biology
Research Interests:
Role of reactive oxygen species in lifespan and host defense / Function of chaperones in stress defense and disease  

 

Paul Jenkins
Assistant Professor of Pharmacology
Accepting new students?
Yes
DEI Statement:
Our lab is committed to welcoming and supporting people from all cultures and identities. We value diversity as it brings new insights, perspectives, and approaches.
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Anti-Racism Training, Bystander Training, first generation-identified
Research Interests:

Neuropsychiatric and neurodevelopmental disorders, Pharmacology, Cell Biology

Cell & Developmental Biology
Research Interests:

We study the signaling mechanism that ensures genome stability during cell division, and its roles in tumorigenesis. Our approach is inter-disciplinary; it includes cell biology, imaging, biochemistry, and computational modeling.  

Biologic and Materials Sciences
Research Interests:

We study molecular mechanisms that regulate craniofacial and cardiac development.

Sundeep Kalantry
Associate Director of Human Genetics
Accepting new students?
Yes
DEI Statement:
We are genetically and epigenetically predisposed to encouraging diverse voices - because, diversity drives innovation and creates a healthy culture in the lab!
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training, Anti-Racism Training, Gender Bias or Discrimination Training
Research Interests:

Epigenetics, chromatin modifications, dosage compensation, embryology, and stem cell biology.

Dept. Pediatrics-Genetics
Research Interests:

The focus of the research in my laboratory is the use of mouse models 1) to understand the mechanisms that lead to birth defects affecting caudal structures in humans, and 2) to understand the mechanisms by which telomere dysfunction causes distinct phenotypes in humans. Prior work in my laboratory has focused on genetically characterizing spontaneous mouse mutants as a platform to understand how disruption of key cellular and developmental processes can lead to structural birth defects and other diseases in humans.  

ULAM/Pathology
Research Interests:

Our laboratory studies the biology of prostate cancer skeletal metastases through a variety of methods. Our current work focuses on examining bone morphogenetic proteins (BMPs) that work through SMAD transcription factors, exploring a signal transduction factor that diminishes prostate cancer metastases, and investigating how interleukin-6 stimulates the androgen receptor in prostate cancer cells.

Rami Khoriaty
Assistant Professor of Internal Medicine
Accepting new students?
Yes
DEI Statement:
We are committed to increasing diversity in the lab and to ensuring that our campus is a place where differences are welcomed and respected. Our lab truly believes that being inclusive and diverse will only make us stronger. Harassment and discrimination have no place in our lab.
Research Interests:

hematopoiesis; erythropoiesis; globin switching, secretory pathway, CRISPR screens

Mentor:
William Dauer
Year:
2016
Undergraduate Institution:
Massachusetts Institute of Technology
Service:
Activities Facilitator at the Ann Arbor Hands-On Museum; Flint water distribution volunteer; TA for ‘lab on wheels’ biotechnology class for 9th grade students; Volunteer judge at Forsythe middle school science fair; PIBS 2016 social committee; CMB Career committee; DEI Career development committee.
Research Interest:
Studying the mechanism of nuclear pore complex formation in neurons and the role of torsinA with regards to nuclear pore biology.
Research Interests:

Studying the mechanism of nuclear pore complex formation in neurons and the role of torsinA with regards to nuclear pore biology

MSTP Student
Mentor:
Ariella Shikanov
Year:
2016
Undergraduate Institution:
Bowdoin College
Research Interests:
Understanding the reproductive consequences of testosterone administration for transgender men using a mouse model. Using an immuno-isolating hydrogel to restore ovarian endocrine function and prevent cancer metastasis.
Pathology
Research Interests:

The Kleer laboratory studies the mechanism by which overepression of EZH2 and down-regulation of CCN6 (WISP3) promote breast cancer invasion and metastasis, and their utility as novel tissue biomarkers of prognosis.

Mentor:
Billy Tsai, Ph.D.
Year:
2018
Undergraduate Institution:
University of Michigan
Research Interests:

ER protein quality control mechanisms and ER-phagy

Nicole Koropatkin
Associate Professor of Microbiology & Immunology, PIBS Associate Director
Accepting New Students?
Yes
Program Involvement
CMB Program Committee, CMB 850 Faculty Evaluators, CMB 850 Student Seminar Coordination, CMB Faculty Review Committee
DEI Statement
My goal as a mentor is to provide trainees with all of the necessary research and professional development tools they need to support their evolution as independent scientists. This requires engaging with each learner as an individual, acknowledging their unique identities and abilities, and asking how I can support their development. Enabling trainees to live full and balanced lives during their training period is key to their sustained success and career longevity.
Trainings and Identities
MORE Mentor Training, Implicit Bias Training, Anti-Racism Training, Intercultural Training, Disability Awareness Training, Bystander Training, Gender Bias or Discrimination Training, Koropatkin Lab Book club, mental health advocate
Research Interests:

microbiome, structural biology, glycoside hydrolases, Bacteroides, starch

Molecular, Cellular, and Developmental Biology
Research Interests:

We use genomics and proteomics to study signaling networks regulating yeast cell growth, cell polarity and cell cycle progression. These networks serve as orthologous models of pathways relevant for: 1) fungal infections of immunocompromised individuals; 2) tumor cell metastasis; 3) cancer research.

Pathology
Research Interests:

Experimental research activities directed at understanding the cellular and molecular mechanisms of cytokine networks that are operative in different immune/inflammatory reactions and host defenses represent the major research efforts in the laboratory.

Mentor:
Manojkumar Puthenveedu
Year:
2016
Undergraduate Institution:
University of Maryland
Research Interest:
Identify and examine the homeostatic regulation of mu-opioid receptor recycling and study its regulatory signaling pathway. Study and identify the cellular molecules required for opioid receptor trafficking and signaling in response to various neuropeptides.
Research Interests:

Identify and examine the homeostatic regulation of mu-opioid receptor recycling and study its regulatory signaling pathway. Study and identify the cellular molecules required for opioid receptor trafficking and signaling in response to various neuropeptides.

MSTP Student
Mentor:
Anthony Antonellis
Year:
2016
Service:
MSTP Ethics Committee (2017), MSTP Retreat Social Committee (2016, 2017), MSTP Retreat Snack Committee (2017), Doctors of Tomorrow Mentor (2015-2016), MiHealth Leadership Team (2016-2017), Teen Night Coordinator at Mott Children’s Hospital (2016)
Research Interest:
Molecular mechanisms of disease-associated tRNA synthetase mutations.
Mentor:
Matthias Truttmann, Ph.D.
Year:
2018
Undergraduate Institution:
Colgate University
Service:
InnoWorks and Rackham Student Government Biological Sciences Representative
Research Interests:

Investigating the role of AMPylation on Hsp70 chaperones in Neurodegenerative Disease models

 

Microbiology & Immunology
Research Interests:

The rapid evolution of RNA viruses makes them particularly challenging targets for vaccines and antiviral drugs. However, a clearer understanding of their unique evolutionary dynamics may suggest novel approaches for control. Our research objective is to understand mechanisms of viral evolution as they relate to transmission and pathogenesis in infected hosts. We study aspects of evolutionary theory in the context of the host-pathogen interface using molecular virology, small animal models, and sequence data from clinical specimens.

Dan Lawrence
Professor of Internal Medicine
Accepting new students?
Yes
DEI Statement:
I am committed to creating a diverse, equitable, and inclusive group. I believe that the more we are exposed to and integrate a wide range of ideas, experiences, cultures, and different ways of thinking, the more likely we are to find the unexpected solution.
Research Interests:

Ischemic stroke, neurodegenerative disease, vascular biology of the CNS, fibrotic disease

Cell and Developmental Biology
Assistant Professor
Research Interests:

The Lee lab aims to understand how pancreatic cancer develops in complex tissue environments, with particular interest in hypoxia and immune cells as critical tumor microenvironment components

Research Interests:

Dr. Lei is on the steering committee of the NCI Cancer Moonshot Immuno-Oncology Translational Network. He is a recipient of the NIH Rising Stars award. His group pioneers at the identification of oncogenic suppressors of the innate immune system. Pattern Recognition Receptors (PPRs) constitute the first line of defense against “non-self” antigens such as tumor neoepitopes. With the characterization of new PRR families, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-I-like receptors (RLRs), and cGAS-STING-mediated cytoplasmic DNA-sensing molecules, novel regulatory...

Scott Leiser
Assistant Professor of Molecular & Integrative Physiology
Accepting new students?
Yes
Trainings and Identities:
Implicit Bias Training, Gender Bias or Discrimination Training
Research Interests:

Aging, metabolism, stress response, neurobiology, genetics

Human Genetics
Research Interests:
My group studies the genetic basis of complex human diseases. Current areas include genetic and genomic analyses of mental disorders, somatic DNA alterations in cancer, and human population genetics.

 

Biologic and Materials Sciences
Research Interests:

Our laboratory focuses on the molecular and cellular basis of neural control of breathing, and how it goes awry in diseases. By molecular and genetic dissection of the breathing control circuit, we study the function of neural populations and pathways underlying breathing rhythms and behaviors, and the pathophysiology of diseases with breathing abnormality.

Internal Medicine - Hematology/Oncology
Research Interests:

Intrinsic and extrinsic mechanisms underlying leukemic stem cell transformation.

Pathology
Research Interests:

Study of the mechanisms of neurodegeneration in CAG/polyglutamine disorders and Niemann- Pick C using mouse and cellular models. Our goal is understand disease pathogenesis and define novel targets for treatment.

CDB
Research Interests:
Our laboratory is investigating the regulatory networks that control nutrient and energy metabolism, using integrated genomic, metabolomic, molecular, and mouse genetic tools. We are interested in exploring the pathogenic mechanisms underlying type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease, and their potential for therapeutic development.

 

Cell and Systems Biology, Cell Physiology, Biochemistry; Microbial Pathogenesis, Immunology
Research Interests:
My research focuses on investigating microorganisms, particularly microbial communities, using systems/synthetic biology approaches. We aim to engineer synthetic microbial consortia for efficient, robust and sustainable biofuel/chemical production; in synergy, we aim to elucidate important natural microbial communities (e.g. human microbiome) by exploiting microfluidics and network modeling tools.

 

Allen Liu
Associate Professor of Mechanical Engineering
Accepting new students?
Probably not for 2021-2022
DEI Statement:
I and my lab value diversity, equity and inclusion very much and it is one of the areas that my group pays attention to. I incorporate DEI into the training in my group and I continue to strive for creating a diverse and inclusive group where everybody can excel.
Trainings and Identities:
MORE Mentor Training, Implicit Bias Training
Research Interests:

Mechanobiology and mechanotransduction, cell migration, clathrin-mediated endocytosis, cytoskeleton, bottom-up synthetic biology

Mats Ljungman
Radiation Oncology
Research Interests:
Mechanisms of transcriptional and post-transcriptional regulation of gene expression in normal physiology and in cancer and neurological disease. Development of novel cancer therapies. We have developed nascent RNA Bru-seq techniques and our lab act as an ENCODE center for mapping transcriptional and post-transcriptional dynamics in human cells.

 

Assistant Professor of Biologic and Materials Science
Accepting new students?
Yes
DEI Statement
We are a team that favors inclusion of people from all different backgrounds.
Trainings and Identities:
MORE Mentor Training
Research Interests:

stem cells, regeneration, gene therapy, cancer

Pediatrics Pulmonary Division
Research Interests:
Work in Lumeng Laboratory focuses on understanding the links between obesity and inflammation and how this impacts human health. We are focused on examining how adipose tissue contributes to inflammation in obesity by understanding the biology of the inflammatory cells that reside in fat. We are particularly interested in the role that adipose tissue macrophages (ATMs), adipose tissue T cells, and other leukocytes play in the biology of adipose tissue.

 

Molecular and Integrative Physiology
Research Interests:

The goals of our research program are to determine the molecular mechanisms by which extracellular signals regulate mesenchymal cell fate decisions, and to improve our understanding of adipocyte metabolism. Mesenchymal stem cells have the capacity to differentiate into a number of cell types, including adipocytes, osteoblasts and myocytes.

Faculty Mentor:
Ariella Shikanov
Year:
2021
Undergraduate Institution:
Brandeis University
Master's Degree:
Reproductive Science and Medicine, Northwestern University
Research Interests:

Interested in human ovarian folliculogenesis and fertility preservation

Mentor:
Sue Hammoud
Year:
2016
Undergraduate Institution:
University of Washington
Research Interests:
Investigating the function of paternally-inherited histones during early embryogenesis.
Research Interests:

Investigating the function of paternally-inherited histones during early embryogenesis.

Internal Medicine
Research Interests:

Interaction between retroviruses and human cellular proteins. Mechanism of action of the DEK oncoprotein. Role of vimentin in immunity and cancer. Kaposi’s Sarcoma.

Mentor:
Daniel Beard
Year:
2018
Undergraduate Institution:
California State University, Fullerton
Honors:
Rackham Merit Fellowship
Research Interests:

 Developing a device to simultaneously measure NADH generation and oxygen consumption in mitochondria in order to investigate the role of metabolic intermediates in bioenergetics. The data collected will be used to develop a computer model of the system. 

Human Genetics
Research Interests:
Molecular genetics of transcription factor mediated neuronal development; gene targeting; studies of human and mouse developmental disorders.

 

Michael McMillan
Mentor:
Sami Barmada
Year:
2017
Undergraduate Institution:
University of Massachusetts Amherst
Ariel McShane
Mentor:
Mats Ljungman
Year:
2017
Undergraduate Institution:
College of Charleston
Human Genetics
Research Interests:
We are studying the molecular basis of neurological disorders using mouse models of epilepsy, movement and behavioral disorders. This work has enabled us to identify several human disease mutations.

 

Mentor:
Mark Chiang, Ph.D.
Year:
2018
Undergraduate Institution:
Michigan State University
Service:
Rackham Student Government Biological and Health Sciences Representative, Executive Position for Student Advocates for Graduate Education (SAGE)
Honors:
2018 Outstanding Master's Student, First Place at MSU Animal Science Graduate Research Forum Oral Presentation, First runner-up at Michigan Alliance for Reproductive Technologies and Sciences Poster Presentation, Larry Ewing Memorial Trainee Travel Fund Grant, First runner-up MSU Graduate Academic Conference Oral Presentation
Research Interests:

My research focuses on investigating Notch cofactors that may regulate Notch signaling in T-cell Acute Lymphoblastic Leukemia   

Mentor:
Marina Pasca Di Magliano
Year:
2016
Research Interest:
Investigating the Role of Arginase 1 in the Pancreatic Cancer Microenvironment.
Pediatrics
Research Interests:
Research efforts are focused on the development of diabetic kidney disease and understanding the mechanisms underlying the role of growth hormone in the causation of certain chronic complications of type 1 diabetes mellitus.

 

Internal Medicine
Research Interests:

Molecular genetics of aggressive breast cancer phenotypes and hereditary breast cancer. Angiogenesis, molecular therapeutics.

Mechanical Engineering
Research Interests:
Kinesin, biomolecular motors, molecular sorting.

 

Molecular and Integrative Physiology
Research Interests:
The Michele Laboratory is interested in the molecular mechanisms of inherited muscular dystrophies, which are lethal diseases of progressive muscle wasting and weakness and cardiomyopathy. We use live cell imaging, molecular techniques, and organ level physiology in muscle cells from animal models and human patients to study cellular mechanisms and identify therapeutic targets. 

 

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