Understanding the role of nuclear hormone receptors in the radiosensitization of breast cancers.
Using cell lines and neuronal models to investigate molecular mechanisms of Ubiquilin-2 (UBQLN2) regulation in normal cellular function and ALS caused by UBQLN2 mutations.
Rho GTPases, cell-cell junctions, cytokinesis, cytoskeleton, mechanotransduction
hypothalamus, brainstem, obesity, diabetes, leptin
Telomerase, Telomeres, Meiosis, Cancer, Stem cells.
Molecular mechanisms of DNA repair, replication, and mutagenesis. Biochemical, biophysical and cellular studies of dynamic protein-DNA interactions. We are interested in basic mechanisms and abnormal mechanisms associated with cancer, immunodeficiency, and aging.
The organization of intracellular components is dependent on the microtubule (MT) cytoskeleton, a network of rod-like filaments that form and disassemble on a rapid timescale. During cell division, MTs assemble into the mitotic spindle, where they generate forces that move chromosomes. MTs are also essential for cytokinesis, where they facilitate cleavage plane specification, constriction of the cleavage furrow, and abscission. The R. Ohi laboratory uses live cell imaging and reconstitution biochemistry to understand how MTs are organized and remodeled during cell division. Over the past...
virus assembly; virus entry; protein trafficking; protein-RNA interaction; protein-membrane interaction
cell migration, signaling, immune responses, cancer invasion
Polyglutamine neurodegenerative disease; Spinocerebellar Ataxia type 3; RNA interference as potential therapy including studies of polyglutamine diseases and Alzheimer's disease; Protein quality control in normal brain function in disease.
Photoreceptor Cell Biology, Membrane Trafficking, Ciliogenesis, Inherited Retinal Disease
Using biochemical and microscopy approaches with cell culture and mouse models, I am fascinated to reveal nuclear Keratin’s role in DNA damage response mechanisms.
Our goal is to identify and investigate genetic mechanisms that are likely to be important for aging and age-related disease in humans by focusing on equivalent, conserved processes in the fruit fly, Drosophila melanogaster. Currently we are studying neuronally-expressed genes involved in linking diet, obesity, and immune function with aging and aging-related disease.
Genetics, eye disease, developmental disorders
The Puthenveedu lab studies how receptor signaling pathways are organized in the cell, focusing on GPCRs relevant to drug addiction. We investigate the exciting new idea that signaling is specified not just by the drug/receptor pair, but also by where in the cell the receptors are located. We use innovative microscopy and molecular genetic techniques to directly track receptor trafficking and function in real time in living cells. The long-term goal is to identify factors that will allow us to actively relocate receptors to specific sites in the cell to fine-tune signaling.
We are interested in the role of protein folding and degradation in endoplasmic reticulum and inflammation in human health and disease. We generate new animal models recapitulating human obesity, type-1 diabetes and type-2 diabetes. Using cell biological, immunological and physiological tools, we strive to make discoveries and gain novel insights into the pathogenesis of human diseases.
Immunity to Virus Infections and Cancers
We study how organisms use gases (CO, CO2, CH4) in metabolism and in metabolic regulation, how metals catalyze reactions and how thiol/disulfide redox switches regulate the activity of enzymes, ion channels and transcriptional regulators. We target systems that are important in human health, environmental biology, and biological energy conversion.
My lab is interested in the molecular mechanisms that define how the combinatorial logic of histone modifications and its dynamic interactions with histone binding proteins encodes stable and heritable patterns of gene expression. We take a multidisciplinary perspective that synthesizes genetics, biochemistry and biophysical approaches to capture cellular processes across different spatial and temporal regimes.
I am interested in understanding and identifying mechanisms of resistance to anti-neoplastic drugs. My work focuses on protein phosphatase 2A (PP2A) - a key regulator of signaling pathways implicated in drug resistance mechanisms.
stem cells, organoids, retina, epigenetics, epitranscriptomics
How the regulation of Semaphorin and Plexin signaling affect brain development.
Evasion of enteric pathogens to the host immune system, and conversely, host immune system resistance against infection by enteric pathogens.
Dr. Russell is studying mechanisms of cardiac and skeletal myofibril assembly, alignment and structural support, topics central to the pathophysiology of, and development of new therapies for, heart failure, myopathy and muscular dystrophy. His laboratory is currently using cell culture as well as mouse and zebrafish model systems to determine the functions of a novel pair of genes, obscurin and obscurin-like 1, that have been cloned and characterized in his laboratory.
Controllability of cell fate decision making. Cell reprogramming and transcription factor delivery modalities.
The Schnell lab investigates multiscale cellular physiology mechanisms. We develop models for the analysis of biochemical reactions and biophysical processes. We used these models to investigate a variety of cell physiology problems. We are particularly interested in investigating the molecular mechanisms of pancreatic b-cells turnover and dysfunction in diabetes, the dynamics of metabolic pathways in cancer cells and the mechanisms of protein misfolding and aggregation in conformational diseases.
Using a human-based model organoid systems to recapitulate early embryonic development in vitro. Particularly interested in using these models to study the regulatory signaling pathways during lung development
Epigenetics, Heterochromatin, S pombe