Research in the Allen Lab is broadly focused on understanding the mechanisms of growth factor and morphogen signaling in development and disease. Specifically, we study the regulation of Hedgehog signaling during embryonic and postnatal development, as well as adult tissue homeostasis, repair and regeneration. Our research employs a wide range of approaches, including mouse genetics, chicken in ovo electroporations, biochemistry, and cell biology. The long-term goal of this work is to apply insights gained from the study of HH signaling in normal contexts to the treatment of a broad...
The Puthenveedu lab studies how receptor signaling pathways are organized in the cell, focusing on GPCRs relevant to drug addiction. We investigate the exciting new idea that signaling is specified not just by the drug/receptor pair, but also by where in the cell the receptors are located. We use innovative microscopy and molecular genetic techniques to directly track receptor trafficking and function in real time in living cells. The long-term goal is to identify factors that will allow us to actively relocate receptors to specific sites in the cell to fine-tune signaling.
tissue engineering, reproduction, biomaterials
