Protein folding, neurodegeneration
I am studying how immunotherapy such as treatment with PDL-1 and CTLA4 affects the immune profile of tumors in mice. We are interested in looking at the differences between responsive and unresponsive tumors. I am also working on the role of how ER stress and glucose deprivation modulate Stat3 activation.
Understanding gene regulatory networks that govern neuronal circuit formation during development.
Understanding the role of mitophagy in colon cancer iron regulation, and investigating metabolic regulations of ER-mitochondria contact sites in cancer.
Using optogenetics, investigate the spatiotemporal regulation of small GTPase RhoA and how it orchestrates actin cytoskeletal dynamics responsible for junctional remodeling and cytokinesis in vertebrate epithelial tissues.
Understanding the role of NETs in neutrophil-mediated immune functions as well as the intercellular signaling cascade surrounding this process.
I am studying the H. pylori virulence factor vacuolating cytotoxin A (VacA). Using single-particle cryo-EM, I am determining VacA's pore-form and characterizing its membrane interactions.
I study the mechanisms of neurodegeneration in Niemann-pick type C disease, an autosomal recessive lysosomal storage disorder
I study the biosynthetic trafficking of G-protein-coupled receptors (GPCRs). GPCR localization to the the cell surface is critical for functional coupling to both extracellular agonists and G-protein effectors on the plasma membrane. Despite the functional importance of GPCR localization to the plasma membrane, relatively little is known about the biosynthetic trafficking of these receptors to the cell surface. I would like to understand how the trafficking of these receptors to the cell surface is regulated and how we can target receptors to the surface to increase signaling.
Protein Quality Control Pathways
The use of cryo-electron microscopy to study the mitochondrial membrane protein, Miro.
Understanding the genetic mechanisms regulating the development and function of neural circuits controlling innate behaviors
Understanding the genetic mechanisms regulating the
development and function of neural circuits controlling innate behaviors.
Role of Ankyrins in neuropsychiatric disorders, such as bipolar disorder and autism spectrum disorder.
Protein Quality Control
I work in a beta-cell biology and diabetes lab. We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.
Our lab studies how epigenetic and metabolic dysregulation influence the development and biology of pediatric brain tumors. My work focuses on a novel epigenetic modifier, EZHIP, which is overexpressed in a subtype of childhood brain cancer known as PF-A ependymomas. EZHIP inhibits polycomb-mediated trimethylation at histone H3 lysine 27 (H3K27me3), a transcriptionally repressive chromatin modifying mark. EZHIP overexpression gives rise to a global reduction in H3K27me3 marks throughout the genome that is poorly prognostic. My project aims to understand the mechanisms regulating EZHIP...
Investigating the role of membrane trafficking in development
Studying the mechanism of nuclear pore complex formation in neurons and the role of torsinA with regards to nuclear pore biology
Investigating the role of AMPylation on Hsp70 chaperones in Neurodegenerative Disease models
Interested in human ovarian folliculogenesis and fertility preservation
Investigating the function of paternally-inherited histones during early embryogenesis.
Developing a device to simultaneously measure NADH generation and oxygen consumption in mitochondria in order to investigate the role of metabolic intermediates in bioenergetics. The data collected will be used to develop a computer model of the system.
My research focuses on investigating Notch cofactors that may regulate Notch signaling in T-cell Acute Lymphoblastic Leukemia
Understanding the role of nuclear hormone receptors in the radiosensitization of breast cancers.
Using cell lines and neuronal models to investigate molecular mechanisms of Ubiquilin-2 (UBQLN2) regulation in normal cellular function and ALS caused by UBQLN2 mutations.