Using biochemical and microscopy approaches with cell culture and mouse models, I am fascinated to reveal nuclear Keratin’s role in DNA damage response mechanisms.
Understanding how polyomaviruses exploit host cell machinery to enter the nucleus
Chromatin, transcription, cell differentiation, cancer
I am interested in understanding and identifying mechanisms of resistance to anti-neoplastic drugs. My work focuses on protein phosphatase 2A (PP2A) - a key regulator of signaling pathways implicated in drug resistance mechanisms.
How the regulation of Semaphorin and Plexin signaling affect brain development.
Evasion of enteric pathogens to the host immune system, and conversely, host immune system resistance against infection by enteric pathogens.
Controllability of cell fate decision making. Cell reprogramming and transcription factor delivery modalities.
Using a human-based model organoid systems to recapitulate early embryonic development in vitro. Particularly interested in using these models to study the regulatory signaling pathways during lung development
Epigenetics, Heterochromatin, S pombe
CRISPR Screening, LDL uptake
Structural biology, microbiomes, host-microbe interactions
Understanding the mechanisms of HPV cellular entry.
Studying the photoreceptor specific role of the transition zone in ciliogenesis and outer segment formation.
Aging and stress response pathways
Protein aggregation dynamics in C. elegans polyglutamine disease models; Behavior and function of physiological polyglutamine-containing proteins
Investigating the mechanism behind recognition/regulation of modified microtubules using cryo-EM.
The mechanisms of myelin targeting in the inner ear.
meiosis, protein structure
Mechanism of neurodegeneration in Amyotrophic Lateral Sclerosis (ALS)
circadian rhythm, genome organization, membraneless organelles